Results 81 to 90 of about 78,400 (265)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Lewis X antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-Type lectin [PDF]

, 2007
Lewis x (Lex, CD15), also known as SSEA-1 (stage specific embryonic antigen-1), is a trisaccharide with the structure Galβ(1–4)Fucα(1–3)GlcNAc, which is expressed on glycoconjugates in human polymorphonuclear granulocytes and various tumors such as colon
A Hittelet, AM Roon van, C Ballaré, D Vestweber, DS Johnston, E Spooncer, EA Jaffé, ED Ball, EG Rizzatti, F Sánchez-Madrid, HC Gooi, HD Soule, IHN Wong, J Kitayama, J Mitoma, J Mordoh, J Mordoh, J-W Liao, JF Harris, JI Yamashita, JL Magnani, José Mordoh, JP Buyon, K Drbal, KL Allendoerfer, KM Skubitz, KM Skubitz, KP Gisbergen van, Kurt Drickamer, L Lucka, M Albrechtsen, M Capurro, M Capurro, M-L Majuri, Mariana Isabel Capurro, María Marcela Barrio, María Teresa Elola, Maureen E. Taylor, MK Robinson, ML Phillips, MM Burdick, N Kawamura, O Ohana-Malka, Peter J. Coombs, PJ Coombs, R Giavazzi, R Kannagi, S D´Costa, S Hakomori, SC Stocks, T Bild, TB Geijtenbeek   +51 more
core   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Approaches to overcome flow cytometry limitations in the analysis of cells from veterinary relevant species [PDF]

, 2020
BACKGROUND: Flow cytometry is a powerful tool for the multiparameter analysis of leukocyte subsets on the single cell level. Recent advances have greatly increased the number of fluorochrome-labeled antibodies in flow cytometry.
Debes, Gudrun F., Hunka, Julia, Riley, John T   +2 more
core   +1 more source

Quantification of antithrombin isoform proportions in plasma samples of healthy subjects, sepsis patients, and in antithrombin concentrates [PDF]

, 2002
Antithrombin (AT) circulates in plasma in two isoforms, AT-alpha (90-95%) and AT-beta (5-10%). AT isoform proportions were measured in plasma samples of 17 healthy subjects and 26 posttraumatic or postoperative septic patients, as well as in 4 ...
Donges, R., Hoffmann, J. N., Inthorn, D., Jochum, M., Muhlbayer, D., Romisch, J., Stauss, H.   +6 more
core   +1 more source

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

Annals of Neurology, EarlyView.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains a significant challenge.
Yue Qiao, Adrien Ter Schiphorst, Yi Xu, Jean‐Claude Baron, Wenbo Zhao   +4 more
wiley   +1 more source

Functions of E-selectin.

Trends in Glycoscience and Glycotechnology, 1994
細胞接着分子であるセレクチンファミリーのE-、P-、L-セレクチンは、共通のドメイン構造を持ち、似たような糖鎖認識を行うので一つのファミリーとなっている。セレクチンはインテグリンや免疫グロブリン様の細胞接着分子と一緒になって、白血球の血管内皮細胞への接着に関与している。これらの接着分子の一過性発現と細胞に特異的な結合特性が白血球を召集して戦地である炎症部位に赴かせるのに役立っている。本論文は、E-セレクチンの構造、糖鎖結合性、および機能についての最近の論文の総説である。
openaire   +2 more sources

Role of S128R polymorphism of E-selectin in colon metastasis formation [PDF]

, 2007
The extravasation of cancer cells is a key step of the metastatic cascade. Polymorphisms in genes encoding adhesion molecules can facilitate metastasis by increasing the strength of interaction between tumor and endothelial cells as well as impacting ...
ALESSANDRO, Riccardo, BRUNO, Loredana, BUETTNER, R, COLOMBA, Paolo, CORRADO, Chiara, DAMIANI, Francesca, DE LEO, Giacomo, FLUGY PAPE', Anna Maria, GULLOTTI, L, RUSSO, Antonio, SEIDITA, Gregorio   +10 more
core   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

E-selectin fills two needs for metastasis [PDF]

Nature Reviews Cancer, 2019
Esposito et al. describe a mechanism for the simultaneous induction of mesenchymal-to-epithelial transition and stem cell traits in disseminating breast cancer cells in the bone, and provide therapeutic opportunities to prevent initiation of bone metastasis.
openaire   +2 more sources