Results 81 to 90 of about 627,511 (265)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

The Effects of Self-Regulated Learning and Other Students’ Helping Behavior on Service Quality in Online Learning:

open access: yesMaketingu Janaru
Service is the process that creates value, and customers participate in its production. Customer participation occurs efficiently when the participation processes are structured.
Hikari Shimosaka
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Mapping Research Trends on Quality in Electronic Services: A Scoping Review

open access: yesAdministrative Sciences
Since the 20th century, quality has become a major strategic concern for both researchers and organizations, serving as a lever for performance and a key factor of differentiation in an increasingly digital environment.
Omar Yaakoubi   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

E-Service Quality at Livin' by Mandiri Users: The Mediating Role of E-Customer Satifaction on E-Customer Loyalty

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
Currently, the banking world is competing fiercely to provide the best service to customers, especially in the realm of Mobile Banking. The purpose of this study was to determine the effect of e-service quality on e-customer loyalty through e-customer ...
Fitriyah Nurjanah   +2 more
doaj   +1 more source

The effect of online service quality and consumers’ motivation on willingness to participate in co-creation activities

open access: yesJurnal Siasat Bisnis, 2019
This study examines factors that encourage consumers to participate in co-creation activities. There are two factors that have been tested concerning their roles in determining the willingness of consumers to participate in co-creation activities.
Agnes Gracia Quita, Sahid Susilo Nugroho
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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