Results 251 to 260 of about 211,577 (291)

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

The E3 ligase tripartite motif 7 drives the progression of non-alcoholic fatty liver disease by targeting DUSP10 degradation in male mice. [PDF]

Nat Commun
Yan FJ, Ding H, Zhang N, Yan SR, Huang MX, Lu JW, Wang YJ, Yan YJ, Li RP, Wang Q.   +9 more
europepmc   +1 more source

The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25. [PDF]

J Biol Chem
Guo Y, Zhu S, Wu W, Cai Y, Sehgal SA, Huang F, Wu H.   +6 more
europepmc   +1 more source

The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration. [PDF]

Bone Res
Lin Z, Lu X, Xu G, Song J, Wang H, Xia X, Lu F, Jiang J, Zhu W, Yu Z, Ma X, Zou F.   +11 more
europepmc   +1 more source

Rice RING E3 Ligase OsRMT1 Negatively Regulates Salt Tolerance by Degrading the Canonical Salt-Responsive Protein OsMBL1. [PDF]

Plant Biotechnol J
Zhang W, Jing K, Zhu J, Shen J, Jiang J, Ge C, Ding H, Wang Y.   +7 more
europepmc   +1 more source

Functional Analysis of the Pepper RING-Type E3 Ligase CaANKR1 Involved in Drought Stress Tolerance via Modulation of Abscisic Acid Signaling. [PDF]

Physiol Plant
Kim M, Lim CW, Kim DS, Lee SC.
europepmc   +1 more source

Application of HIV-1 viral protein R-derived-peptides as new E3 ligase-binding components of BRD4 degraders. [PDF]

RSC Chem Biol
Tsuji K, Huang X, Miyamoto M, Sukegawa S, Yokoo H, Takeuchi H, Demizu Y, Tamamura H.   +7 more
europepmc   +1 more source

Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4

Spiteri VA, Segal D, Correa-Saez A, Iso K, Casement R, Munoz i Ordono M, Nakasone MA, Sathe G, Schatz C, Peters HE, Doward M, Kainacher L, Cowan AD, Ciulli A, Winter GE.   +14 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

E3 ligase ligand chemistries: from building blocks to protein degraders.

Chemical Society Reviews, 2022
In recent years, proteolysis-targeting chimeras (PROTACs), capable of achieving targeted protein degradation, have proven their great therapeutic potential and usefulness as molecular biology tools.
Izidor Sosič, Aleša Bricelj, C. Steinebach   +2 more
semanticscholar   +1 more source