Results 231 to 240 of about 176,319 (351)

Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang   +5 more
wiley   +1 more source

The E3 ubiquitin ligase STUB1 inhibits Senecavirus A replication by mediating VP1 ubiquitination and proteasomal degradation. [PDF]

J Virol
Zeng P, Mao J, Guo J, Yang X, Shi Y, Wang X, Song J, Zhou J, Hou L, Liu J.   +9 more
europepmc   +1 more source

E3 Ubiquitin-Protein Ligase RING2 [PDF]

, 2020
openaire   +1 more source

MARCH7 E3 ubiquitin ligase is highly expressed in developing spermatids of rats and its possible involvement in head and tail formation

, 2013
博強 趙
openalex   +1 more source

E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation

Vartika Sharma, Nalani Sachan, Bappi Sarkar, Mousumi Mutsuddi, Ashim Mukherjee   +4 more
openalex   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

The E3 ubiquitin ligase MARCH9 alleviates pyroptosis by regulating NLPR3 ubiquitination following myocardial ischemia reperfusion. [PDF]

Cell Mol Life Sci
Lu H, Ma G, Ding C, Wang P, Ruan Q, Zeng Y, Ma L, Lu M, Li Y, Sun W.   +9 more
europepmc   +1 more source

Enhancing polyphenol synthesis and antioxidant activity in Camellia sinensis using shikimic and salicylic acids

JSFA reports, EarlyView.
Abstract Background Camellia sinensis, widely consumed as tea, is the second most popular beverage globally and is valued for its health benefits. However, environmental stressors pose a significant challenge to the tea industry. This study investigates the potential of shikimic acid (ShA) and its derivative, salicylic acid (SA), as inducers to enhance
Mir Sultanul Arafin, Shelina Akter Sheuli, Sadia Sultana, Mahir Azmal, Ajit Ghosh   +4 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]

FEBS Open Bio
Soeda S, Montrose M, Takahashi A, Ishida R, Burriel S, Ohmine N, Natsume T, Adachi S, Kim M, Yamamoto T.   +9 more
europepmc   +1 more source

E3 Ubiquitin-Protein Ligase HERC2 [PDF]

, 2020
openaire   +1 more source