Results 141 to 150 of about 1,772 (177)

African swine fever virus early protein pI73R suppresses the type-I IFN promoter activities. [PDF]

Virus Res
Lai DC, Chaudhari J, Vu HLX.
europepmc   +1 more source

Charge-reversal proteolysis polymers enable tissue-specific STING degradation in rheumatoid arthritis. [PDF]

Proc Natl Acad Sci U S A
He X, Gong L, Zhang J, Pang X, Li Y, Wei W, Cui Y, Lin Z.   +7 more
europepmc   +1 more source

Pilot ED Wastewater Surveillance During the 2024-2025 Respiratory Virus Season.

JAMA Netw Open
Renfro Z, Zulli A, Levy V, Nawy R, Mercado A, Jong S, Salinas JL, Eastwood H, Below C, Boehm AB, Parsonnet J, Bennett CL.   +11 more
europepmc   +1 more source

The Orf Virus E3L Homologue Is Able to Complement Deletion of the Vaccinia Virus E3L Gene in Vitro but Not in Vivo

Virology, 2003
Orf virus (OV), the prototypic parapoxvirus, is resistant to the effects of interferon (IFN) and this function of OV has been mapped to the OV20.0L gene. The protein product of this gene shares 31% amino acid identity to the E3L-encoded protein of vaccinia virus (VV) that is required for the broad host range and IFN-resistant phenotype of VV in cells ...
Colin McInnes, Bertram L Jacobs, Andy Mercer   +2 more
exaly   +4 more sources

Antagonizing Activity of Vaccinia Virus E3L Against Human Interferons in Huh7 Cells

Virology, 2008
The E3L protein of vaccinia virus (VV) is well known for its capacity to evade cellular innate antiviral immunity related to interferon (IFN), for example PKR and RNaseL mediated antiviral activities. However, due to the limited range of cells that support VV E3L deletion mutant replication, the full capacity of E3L inhibiting the innate immune ...
Yvon Deschambault
exaly   +4 more sources

Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model. [PDF]

Journal of Virology, 2001
ABSTRACT The vaccinia virus (VV) E3L gene is responsible for providing interferon (IFN) resistance and a broad host range to VV in cell culture. The E3L gene product contains two distinct domains. A conserved carboxy-terminal domain, which is required for the IFN resistance and broad host range of the virus, has been shown to ...
Bertram L Jacobs
exaly   +4 more sources

Anti-Apoptotic and Oncogenic Properties of the dsRNA-Binding Protein of Vaccinia Virus, E3L [PDF]

Oncogene, 2002
The vaccinia virus (VV) E3L gene encodes a dsRNA binding protein that inhibits activation of the IFN-induced, dsRNA-dependent protein kinase, (PKR), the 2-5A synthetases/RNase L system and other dsRNA dependent pathways, thus leading to efficient VV replication.
Susana Guerra, Jesus Gil, Mariano Esteban   +2 more
exaly   +3 more sources

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Structural Study of Novel Vaccinia Virus E3L and dsRNA-Dependent Protein Kinase Complex

Biochemical and Biophysical Research Communications, 2023
E3L (RNA-binding protein E3) is one of the key IFN resistance genes encoded by VV and consists of 190 amino acids with a highly conserved carboxy-terminal double-stranded RNA-binding domain (dsRBD). PKR (dsRNA-dependent protein kinase) is an IFN-induced protein involved in anti-cell and antiviral activity.
Chang Woo Han, Mi Suk Jeong, Hyeon Jin Kim   +2 more
exaly   +3 more sources

Rescue of Vaccinia Virus Lacking the E3L Gene by Mutants of E3L. [PDF]

Journal of Virology, 1995
Vaccinia virus with the E3L gene deleted was able to replicate in RK-13 but not HeLa cells. This host range phenotype could be complemented by an E3L gene expressed transiently from a plasmid. Analysis of mutants of E3L indicates that the ability to complement deletion of E3L correlates with the ability of mutated proteins to bind double-stranded RNA ...
Bertram L Jacobs
exaly   +3 more sources