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Attenuated NYCBH Vaccinia Virus Deleted for the E3L Gene Confers Partial Protection Against Lethal Monkeypox Virus Disease in Cynomolgus Macaques [PDF]
Vaccine, 2011 The New York City Board of Health (NYCBH) vaccinia virus is the currently licensed vaccine for use in the US against smallpox. The vaccine under investigation in this study has been attenuated by deletion of the innate immune evasion gene, E3L, and shown to be protective in homologous virus mouse challenge and heterologous virus mouse and rabbit ...
Bertram L Jacobs
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Virus Genes, 2000
We report the results of a two-hybrid study which identified clones from a HeLa cDNA library that interact with the vaccinia virus protein E3L. These clones encode the nuclear protein SUMO-1 (also known as PIC-1, sentrin or GMP-1); the cytoplasmic ribosomal protein L23a; and a small peptide sequence of unknown significance.
Shaun Heaphy
exaly +4 more sources
We report the results of a two-hybrid study which identified clones from a HeLa cDNA library that interact with the vaccinia virus protein E3L. These clones encode the nuclear protein SUMO-1 (also known as PIC-1, sentrin or GMP-1); the cytoplasmic ribosomal protein L23a; and a small peptide sequence of unknown significance.
Shaun Heaphy
exaly +4 more sources
Virology, 1993
The E3L gene of vaccinia virus encodes the double-stranded (ds) RNA binding proteins p20 and p25 that exhibit inhibitory activity for the IFN-induced, P1/elF-2 alpha protein kinase. A region in the E3L encoded proteins (residues 156-180) shares a high degree of similarity with several proteins that bind double-helical RNA including the P1/elF-1 alpha ...
H W, Chang, B L, Jacobs
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The E3L gene of vaccinia virus encodes the double-stranded (ds) RNA binding proteins p20 and p25 that exhibit inhibitory activity for the IFN-induced, P1/elF-2 alpha protein kinase. A region in the E3L encoded proteins (residues 156-180) shares a high degree of similarity with several proteins that bind double-helical RNA including the P1/elF-1 alpha ...
H W, Chang, B L, Jacobs
openaire +2 more sources
Cell Death and Differentiation, 2006 Infection with viruses often protects the infected cell against external stimuli to apoptosis. Here we explore the balance of apoptosis induction and inhibition for infection with the modified vaccinia virus Ankara (MVA), using two MVA mutants with ...
Gerd Sutter +2 more
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Journal of Interferon & Cytokine Research, 1998
Vaccinia virus (VV) has been shown to be relatively resistant to the antiviral effects of interferon-alpha (IFN-alpha) and to rescue replication of IFN-sensitive viruses, such as encephalomyocarditis virus (EMCV) and vesicular stomatitis virus (VSV), from the antiviral effects of IFN.
S T, Shors +4 more
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Vaccinia virus (VV) has been shown to be relatively resistant to the antiviral effects of interferon-alpha (IFN-alpha) and to rescue replication of IFN-sensitive viruses, such as encephalomyocarditis virus (EMCV) and vesicular stomatitis virus (VSV), from the antiviral effects of IFN.
S T, Shors +4 more
openaire +2 more sources
Effect of MSC treatment on LPS-induced inflammation, emphysema and atherosclerosis inE3Lmice
3.3 Mechanisms of Lung Injury and Repair, 2015Background: COPD patients have an increased risk of cardiovascular diseases (CVD), which may be linked through systemic inflammation triggered by smoke and microbial exposure. Recent studies show the promising antiinflammatory and regenerative effects of mesenchymal stromal cells (MSC).
Padmini Khedoe +11 more
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Nederlands Tijdschrift voor Diabetologie, 2012
The central melanocortin system is known to regulate food intake, adiposity, blood pressure, and glucose metabolism. Recently, it has been reported that the melanocortin system also regulates cholesterol metabolism. Studies in wild-type rats and mice showed increased HDL cholesterol levels upon chronic central infusion with SHU9119, a melanocortin 3/4 ...
Sander Kooijman +5 more
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The central melanocortin system is known to regulate food intake, adiposity, blood pressure, and glucose metabolism. Recently, it has been reported that the melanocortin system also regulates cholesterol metabolism. Studies in wild-type rats and mice showed increased HDL cholesterol levels upon chronic central infusion with SHU9119, a melanocortin 3/4 ...
Sander Kooijman +5 more
openaire +1 more source
Journal of Chemical Information and Modeling
Targeted protein degradation (TPD) is an innovative drug discovery approach that leverages small molecules to induce proximity between a protein of interest (POI) and an E3 ubiquitin ligase (E3L) for selective degradation. Among TPD modalities, proteolysis-targeting chimeras (PROTACs) present unique challenges for computational modeling due to their ...
Roberto Jiménez-Boi +6 more
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Targeted protein degradation (TPD) is an innovative drug discovery approach that leverages small molecules to induce proximity between a protein of interest (POI) and an E3 ubiquitin ligase (E3L) for selective degradation. Among TPD modalities, proteolysis-targeting chimeras (PROTACs) present unique challenges for computational modeling due to their ...
Roberto Jiménez-Boi +6 more
openaire +2 more sources
Interaction between E3L and K3L proteins of vaccinia virus.
BioInfoBank Library Acta, 2013openaire +1 more source