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The papillomavirus E7 proteins
E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus E1A protein, which are also conserved in the simian vacuolating virus 40 large tumor antigen.
Roman, Ann, Munger, Karl
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GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T cell responses leading to tumor regression. [PDF]
BACKGROUND:Prophylactic vaccines are available for women and girls not yet infected with HPV, but women already infected with HPV need a treatment to prevent progression to high-grade cervical lesions and cancer.
Michaël Esquerré +7 more
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There is an intriguing relation between quantum information theory and super gravity, discovered by M. J. Duff and S. Ferrara. It relates entanglement measures for qubits to black hole entropy, which in a certain case involves the quartic invariant on the 56-dimensional representation of the Lie group E7.
Cerchiai Bianca Letizia, van Geemen Bert
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Coronary Fistulas: A Case Series
Coronary artery fistula is an uncommon finding during angiographic exams. We report a case series of five patients with congenital coronary fistulas.
Nada Fennich +6 more
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The canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein. [PDF]
The high-risk HPV E6 and E7 proteins cooperate to immortalize primary human cervical cells and the E7 protein can independently transform fibroblasts in vitro, primarily due to its ability to associate with and degrade the retinoblastoma tumor suppressor
Jingang Wang +4 more
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Persistent infection with the human papillomavirus 16 (HPV 16) is the cause of half of all cervical carcinomas (CC) cases. Moreover, mutations in the oncoproteins E6 and E7 are associated with CC development.
Ramón Antaño-Arias +8 more
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Toward a cognitive science of markets: economic agents as sense-makers
Behavioral economics aspires to replace the agents of neoclassical economics with living, breathing human beings. Here, the author argues that behavioral economics, like its neoclassical counterpart, often neglects the role of active sense-making that ...
Johnson Samuel G.B.
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Improved immunodetection of human papillomavirus E7 [PDF]
Human papillomavirus E7 (HPV E7) is a viral oncoprotein that plays an important role in cervical carcinogenesis through binding with retinoblastoma protein (Rb). Inactivation of Rb by E7 is necessary but not sufficient for cellular transformation, suggesting other protein-protein interactions are required for E7-mediated cellular transformation aside ...
Ju-Hong, Jeon +6 more
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HPV16 infections are associated with a variety of cancers and there is compelling evidence that the transforming activity of HPV16 critically depends on the expression of the viral oncoproteins E6 and E7. Therapeutic cancer vaccines capable of generating
Christian Grunwitz +8 more
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Tocilizumab, a humanized anti-human interleukin-6 (IL-6) receptor monoclonal antibody, is beneficial for treating autoimmune conditions such as rheumatoid arthritis (RA).
Asumi Tada +3 more
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