Results 31 to 40 of about 86,081 (238)

MODERN ASPECTS OF HUMAN PAPILLOMAVIRUS VACCINATION

Безопасность и риск фармакотерапии, 2018
Human papillomavirus refers to DNA-containing viruses and infects the skin and mucosal epithelium. One common way is to change the  expression of cellular genes by integrating the viral genome into  cellular DNA.
O. S. Alyautdina, M. A. Darmostukova
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

E7-QK induces endothelial tubule formation.

, 2019
HUVECs were pre-labelled with Cell Tracker Green dye, and then seeded onto GELTREX matrices in either serum-free media (untreated) or serum-free media containing 50 ng/mL rVEGF, or 25 nM of either QK or E7-QK peptides.
Andrew S. Curry (6444023), Nicholas W. Pensa (6444020), Susan L. Bellis (316256), Michael S. Reddy (6444026)   +3 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Effect of polyp regression and reduction on treatment efficacy in polypoidal choroidal vasculopathy treated with aflibercept

Scientific Reports
Intravitreal injection of aflibercept (IVA) has successfully treated polypoidal choroidal vasculopathy (PCV), and polyp morphology is an important indicator of treatment efficacy.
Kaori Sayanagi, Satoko Fujimoto, Chikako Hara, Yoko Fukushima, Kazuichi Maruyama, Ryo Kawasaki, Shigeru Sato, Kohji Nishida   +7 more
doaj   +1 more source

Anti-Interleukin-6 Receptor Antibody Therapy-Induced Retinopathy in a Patient with Rheumatoid Arthritis

Case Reports in Rheumatology, 2012
Tocilizumab, a humanized anti-human interleukin-6 (IL-6) receptor monoclonal antibody, is beneficial for treating autoimmune conditions such as rheumatoid arthritis (RA).
Asumi Tada, Noriyasu Hashida, Toshio Tanaka, Kohji Nishida   +3 more
doaj   +1 more source

Drop‐on‐Demand Printed Negative Dielectric Anisotropy Liquid Crystal Droplets for Adaptive Complex Beam Manipulation and Assessment

Advanced Functional Materials, EarlyView.
Printed negative‐dielectric‐anisotropy liquid‐crystal droplets enable multidimensional full‐vectorial optical‐field sensing across polarization, phase, and wavelength, while also generating tunable skyrmionic‐like complex optical fields. ABSTRACT Adaptive manipulation of vectorial optical fields is important for optical metrology, imaging, and ...
Jinge Guo, Xuke Qiu, Runchen Zhang, Qihao Han, Liangyu Deng, Yishun Lu, Zimo Zhao, Mengmeng Li, Waqas Kamal, Junseok Ma, Yongge Ma, Steve J. Elston, Alfonso A. Castrejón‐Pita, Stephen M. Morris, Chao He   +14 more
wiley   +1 more source

Control of Spontaneous HPV16 E6/E7 Expressing Oral Cancer in HLA-A2 (AAD) Transgenic Mice with Therapeutic HPV DNA Vaccine

Journal of Biomedical Science, 2021
Background Human Papillomavirus type 16 (HPV16) has been associated with a subset of head and neck cancers. Two HPV encoded oncogenic proteins, E6 and E7, are important for the malignant progression of HPV-associated cancers.
Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung, T. -C. Wu   +6 more
doaj   +1 more source

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

Advanced Materials, EarlyView.
A wearable electrochemical microneedle patch integrates Prussian Blue redox transduction with molecularly imprinted polymer recognition for reagent‐free sampling and detection of thrombo‐inflammatory biomarkers in dermal interstitial fluid. The platform tracks thrombin and inflammatory cytokines with sensitive in vitro, ex vivo, and in vivo performance,
Mahmoud Ayman Saleh, Peyman GhavamiNejad, Arash Khorrami Jahromi, Sanjana Srikant, Sripadh Guptha Yedire, Fatemeh Keyvani, Roozbeh Siavash Moakhar, Sajad Shiekh, Mackenzie Graham, Joe Quadrilatero, Mahla Poudineh, Sara Mahshid   +11 more
wiley   +1 more source

Therapeutic dendritic cell vaccination against human papillomavirus [PDF]

, 2009
Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually.
Nurkkala Karlsson, Merja
core   +1 more source