Results 51 to 60 of about 86,081 (238)
Advanced Science, EarlyView.Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He +10 more
wiley +1 more source
mBio, 2015 Transcripts of human papillomavirus 16 (HPV16) E6 and E7 oncogenes undergo alternative RNA splicing to produce multiple splice isoforms. However, the importance of these splice isoforms is poorly understood.
Masahiko Ajiro, Zhi-Ming Zheng
doaj +1 more source
Localisation of human papillomavirus 16 E7 oncoprotein changes with cell confluence. [PDF]
PLoS ONE, 2011 E7 is one of the best studied proteins of human papillomavirus type 16, largely because of its oncogenic potential linked to cervical cancer. Yet the sub-cellular location of E7 remains confounding, even though it has been shown to be able to shuttle ...
Joanna Laurson, Kenneth Raj
doaj +1 more source
Detecção molecular do DNA e RNAm do HPV e sua aplicabilidade na triagem do câncer cervical [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011O câncer de colo uterino representa o segundo tipo de câncer mais comum entre as mulheres.
Martins, Toni Ricardo
core
Advanced Science, EarlyView.We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang +19 more
wiley +1 more source
Temperature‐Tunable Cholesteric Liquid Crystal Optical Combiners for Extended Reality Applications
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.Recent advancements in extended reality highlight their potential to enhance traditional displays like liquid crystal displays and organic light‐emitting diode screens. This article introduces an innovative cholesteric liquid crystal‐based optical combiner for head‐mounted displays, enabling seamless transitions between augmented reality, virtual ...
Yuanjie Xia +6 more
wiley +1 more source
Induced blue phase of cholesteric-nematic mixtures under the action of acetone vapors
Фізика і хімія твердого тілаLiquid crystals can exhibit structural orientational order. The creation of a mixture with the addition of chiral molecules to the nematic liquid crystal induces helical twisting, the axis of which is directed perpendicular to the cell surfaces.
Z.M. Mykytyuk +7 more
doaj +1 more source
High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation
mBio, 2016 The major transformation activity of the high-risk human papillomaviruses (HPV) is associated with the E7 oncoprotein. The interaction of HPV E7 with retinoblastoma family proteins is important for several E7 activities; however, this interaction does ...
Elizabeth A. White +2 more
doaj +1 more source
Fusion protein vaccines targeting two tumor antigens generate synergistic anti-tumor effects. [PDF]
PLoS ONE, 2013 INTRODUCTION: Human papillomavirus (HPV) has been consistently implicated in causing several kinds of malignancies, and two HPV oncogenes, E6 and E7, represent two potential target antigens for cancer vaccines.
Wen-Fang Cheng +6 more
doaj +1 more source
HPV18 E6 and E7 mRNA and relative protein expressions in Hep G2 transfected with E7-siRNA.
, 2013 (A) Effective siRNAs were screened using RT-PCR assays from three siRNAs targeting the E7 gene and two of three siRNAs (siRNA E7-63 and siRNA E7-63 112) were more effective.
Ling Chen (25698) +10 more
core +1 more source