Results 51 to 60 of about 57,881 (149)

Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF.

PLoS ONE, 2014
High-risk human papillomavirus oncoproteins E6 and E7 play a major role in HPV-related cancers. One of the main functions of E7 is the degradation of pRb, while E6 promotes the degradation of p53, inactivating the p14ARF-p53 pathway.
Isabelle Dichamp, Paule Séité, Gérard Agius, Alice Barbarin, Agnès Beby-Defaux   +4 more
doaj   +1 more source

The retinoblastoma protein contributes to maintaining the stability of HPV E7 in cervical cancer cells

Journal of Virology
High-risk human papillomaviruses (HR HPV)-16 and -18, and other closely related subtypes, are associated with at least 90% of human cervical cancers.
Ifeoluwa Gbala, Nezka Kavcic, Lawrence Banks   +2 more
doaj   +1 more source

Evaluation of HPV16 E7 expression in head and neck carcinoma cell lines and clinical specimens

Scientific Reports, 2020
Human papillomavirus (HPV) 16 infection in the oropharynx is one of the major risk factors for oropharyngeal carcinoma. Although the HPV E6 and E7 proteins are known to have a role in head and neck carcinogenesis, whether their expression is maintained ...
Koji Kitamura, Keisuke Nimura, Rie Ito, Kotaro Saga, Hidenori Inohara, Yasufumi Kaneda   +5 more
doaj   +1 more source

New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccines

Infectious Agents and Cancer
Background Development of immunotherapies and vaccines to treat HPV16-associated cancer requires reliable/effective small animal models. We developed such a model based on the murine mammary gland adenocarcinoma cells engineered to express HPV16 ...
Juris Jansons, Daria Avdoshina, Alesja Dudorova, Elena Royo Rubio, Liba Sokolovska, Dmitry Perminov, Ilze Lindenberga, Hannes Nicolai, Svetlana Gebrila, Sona Chowdhury, Dace Skrastina, Jurijs Nazarovs, Joel M. Palefsky, Maria Isaguliants   +13 more
doaj   +1 more source

Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA

Virology Journal, 2007
Background Human papillomavirus (HPV) infection is known to be the most important etiologic factor of cervical cancer. There is no HPV specific therapy available for treatment of invasive squamous cell carcinoma of the cervix and its precursor lesions ...
Johansson Bo, Syrjänen Stina, Kari Ilkka, Peri Piritta, He Bin, Roizman Bernard, Hukkanen Veijo   +6 more
doaj   +1 more source

Neutral currents in the E7 theory

Physics Letters B, 1979
Abstract We show that in the E 7 scheme of grand unification there is a possibility to describe weak and electromagnetic interactions by the gauge group SU(3) × [U (1)] 3 . Being in good agreement with the available data, the E 7 model yields such specific predictions as small W- and Z-boson masses and μ -e non-universality in neutral currents.
R. Lednický, V. Tzeitlin
openaire   +1 more source

MmuPV1 E7 promotes phenotypes associated with “high-risk” HPV infection in mouse keratinocytes

Journal of Virology
The E7 oncoprotein of mouse papillomavirus (MmuPV1) plays a pivotal role in both viral infection and cancer development. While earlier studies have identified key cellular targets of MmuPV1 E7, such as pRB and PTPN14, the broader impact of MmuPV1 E7 on ...
Kayla R. Duxbury, Liyan Zhang, Laura K. Muelhbauer, Mitchell Hayes, Joshua J. Coon, Megha Padi, James C. Romero-Masters   +6 more
doaj   +1 more source

HPV16 E7 modulates the cell surface expression of MET and CD109 via the AP2 complex

Tumour Virus Research
Multiple cellular pathways are affected by HPV E6 and E7 oncoproteins, including endocytic and cellular trafficking. HPV-16 E7 can target the adaptor protein (AP) complex, which contains proteins important during endocytosis transport.
Oscar Trejo-Cerro, Om Basukala, Michael P. Myers, Lawrence Banks   +3 more
doaj   +1 more source

Negative dimensions and E7 symmetry

Nuclear Physics B, 1981
Abstract The invariant length and volume which characterize the Lorentz group are extended to a quadratic and a quartic supersymmetric invariant. The symmetry group of the Grassmann sector can be SO(2), SU(2), SU(2) × SU(2) × SU(2), Sp(6), SU(6), SO(12) or E 7 , which are also possible global symmetries of extended supergravities.
openaire   +1 more source

ZEUS E6, HADES E8, HERMES E7, HEFESTO E7

This final report consolidates the communication, dissemination, exploitation, and academic activities carried out in the CERBERUS 5G project, with contributions from the ZEUS, HADES, HERMES, and HEFESTO subprojects. It documents the project’s impact, lessons learned, and synergies, providing a foundation for future developments in cybersecurity and ...
openaire   +1 more source