Results 101 to 110 of about 441,758 (309)
Study of fluid flow within the hearing organ [PDF]
arXiv, 2017 Georg Von Bekesy was awarded a nobel price in 1961 for his pioneering work on the cochlea function in the mammalian hearing organ. He postulated that the placement of sensory cells in the cochlea corresponds to a specific frequency of sound. This theory, known as tonotopy, is the ground of our understanding on this complex organ.
arxiv
Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae [PDF]
, 2014 Poster presentation - Theme 3: Development & stem cellsThe Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis.
Hui, CC +4 more
core
Advanced Science, EarlyView.A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen +8 more
wiley +1 more source
Role of Dach1 revealed using a novel inner ear-specific Dach1-knockdown mouse model
Biology Open, 2019 The Dach1 gene is expressed in the inner ear of normal mouse embryos in the area that differentiates into the cochlear stria vascularis (SV). We hypothesised that Dach1 downregulation in the inner ear would lead to SV dysplasia.
Toru Miwa +5 more
doaj +1 more source
The Active Traveling Wave in the Cochlea [PDF]
, 2003 A sound stimulus entering the inner ear excites a deformation of the basilar membrane which travels along the cochlea towards the apex. It is well established that this wave-like disturbance is amplified by an active system. Recently, it has been proposed that the active system consists of a set of self-tuned critical oscillators which automatically ...
arxiv +1 more source
Advanced Science, EarlyView.D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei +18 more
wiley +1 more source
Inner Ear Therapeutics: An Overview of Middle Ear Delivery
Frontiers in Cellular Neuroscience, 2019 There are a variety of methods to access the inner ear and many of these methods depend on utilizing the middle ear as a portal. In this approach the middle ear can be used as a passive receptacle, as part of an active drug delivery system, or simply as ...
Jaimin Patel +6 more
doaj +1 more source
LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)
Signal Transduction and Targeted Therapy, 2022 Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide. However, the presence of the blood-labyrinth barrier (BLB) on the surface of the inner ear capillaries greatly hinders the effectiveness of ...
Xi Shi +25 more
doaj +1 more source
Nonlinear dynamics of the mammalian inner ear [PDF]
arXiv, 2015 A simple nonlinear transmission-line model of the cochlea with longitudinal coupling is introduced that can reproduce Basilar membrane response and neural tuning in the chinchilla. It is found that the middle ear has little effect on cochlear resonances, and hence conclude that the theory of coherent reflections is not applicable to the model.
arxiv
Frequency dependence of prestin: Intrinsic transition rates and viscoelastic relaxation [PDF]
arXiv, 2020 Outer hair cells in the inner ear is important for the sensitivity, frequency selectivity, and dynamic range of the mammalian ear. Such a physiological role of outer hair cells is thought to be based an amplifying effect of those cells, which have mechanosensitive their hair bundles and motile cell body embedding prestin, a membrane protein with ...
arxiv