Results 131 to 140 of about 1,167,163 (294)
Common neural correlates of disgust processing in childhood maltreatment and peer victimisation
BJPsych OpenBackground Childhood maltreatment and peer victimisation are common sources of early-life interpersonal stress. Childhood maltreatment is associated with atypical frontolimbic emotion processing and regulation, and increased vulnerability for self-harm ...
Lena Lim, Katya Rubia, Steve Lukito
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Role and treatment of early maladaptive schemas in Vietnam veterans with PTSD
, 2010 The role of early maladaptive schemas in understanding and treating post-traumatic stress disorder (PTSD) was investigated. The first study examined the role of perceived adverse parenting and early maladaptive schemas in the development of PTSD in ...
Cockram, D.M., Lee, C.W., Drummond, P.D.
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
InsectsInsect populations are increasingly exposed to concurrent climate warming and agrochemical contamination, yet how these stressors interact to influence reproductive performance remains poorly understood.
David A. Sánchez-Rodríguez +3 more
doaj +1 more source
Early-Life Stress Triggers Juvenile Zebra Finches to Switch Social Learning Strategies.
, 2015 Stress during early life can cause disease and cognitive impairment in humans and non-humans alike. However, stress and other environmental factors can also program developmental pathways.
KA Spencer (14473998) +2 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Frontiers in PharmacologyChronic pain is increasingly recognized as a multidimensional condition in which neuroimmune interactions shape disease vulnerability and persistence.
Carmela Belardo +15 more
doaj +1 more source
Alteration of somatosensory response in adulthood by early life stress.
, 2015 Early-life stress is well known as a critical risk factor for mental and cognitive disorders in adulthood. Such disorders are accompanied by altered neuro- (synapto-) genesis and gene expression.
Noriyuki eKoibuchi +3 more
core +1 more source