Results 141 to 150 of about 13,944,920 (244)

Early-life stress reduces senescence in the field for an indeterminately growing ectotherm. [PDF]

Evol Lett
Morgan W, Cameron H, Marshall D.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Early-Life Stress Programs a Vulnerable Renal Phenotype Under Metabolic Challenge in a Murine Model. [PDF]

Biomolecules
Duque-Colorado J, Vásquez B.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

NMDA receptor-dependent structural plasticity links early life stress to persistent aggression. [PDF]

Neurobiol Stress
Jacobs JT, Nordman JC.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Early Life Stress Affects Human Decision Making by Increasing Expectations of Volatility. [PDF]

Dev Sci
Smith KE, Piray P, Teal A, Gok S, Pollak SD.   +4 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Editorial: Long-lasting neurobehavioral effects of early-life events

Frontiers in Neuroscience
Rossella Ventura, Rossella Ventura, Matteo Di Segni, Matteo Di Segni, Mónica Santos, Mónica Santos, Mónica Santos, Carmen Agustín-Pavón, Jose V. Torres-Pérez   +8 more
doaj   +1 more source

Profiles of Early Life Stress and Their Interaction With Proximal Stress in Early Adulthood: A Person-Centered Approach. [PDF]

J Clin Psychol
Park J, Freeman C, Hong S, Weinberg A.
europepmc   +1 more source