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Plasticity of the epigenome during early-life stress

Seminars in Cell & Developmental Biology, 2018
Early life adversity remains a significant risk factor for the development of a host of negative behavioural and pathological outcomes in adulthood long after the stressor is over. Recent evidence indicates that these lasting effects of ELS may occur via alterations in the epigenetic landscape.
Burns, S. Barnett   +4 more
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Early life stress in depression susceptibility

Science, 2017
Neurodevelopment The linkage between stress early in life and behavioral depression in adulthood is complex. Pena et al. were able to define a time period in early development when mice are especially susceptible to stress. Mice subjected to stress during this time period were less resilient to stress in adulthood.
openaire   +2 more sources

Stress in early life inhibits neurogenesis in adulthood

Trends in Neurosciences, 2005
Both structure and function of the hippocampus are altered by stress: by increasing levels of corticosteroids, stress causes atrophy of CA3 pyramidal cell dendrites, inhibits adult neurogenesis in the dentate gyrus, and impairs hippocampus-dependent learning.
Yashmin J G, Karten   +2 more
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Early Adolescence as a Life Stress

1980
Relationships between life stress and susceptibility to various physical and psychological disorders has been shown by many studies. These issues deserve careful study in early adolescence in particular. The concept of early adolescence is relatively new.
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Early Life Stress and Psychopathology

2018
Exposure to chronic or severe stressful life events during childhood and adolescence—frequently referred to as early life stress (ELS) or childhood adversity—has powerful and lasting associations with psychopathology across the life course. This chapter reviews the growing body of research on ELS and psychopathology across the life course, with a ...
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Effects Of Stress In Early Life

2004
Abstract International adoptees encounter stress both prenatally and postnatally (Table 8–1). Most are products of unwanted pregnancies. After birth, many suffer from abandonment, institutionalization, malnutrition, recurrent illnesses, environmental deprivation, and/or emotional neglect.
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The Kindling/Sensitization Model and Early Life Stress

2020
Few animal models address the characteristics of the longitudinal course of bipolar disorder. However, behavioral sensitization (to recurrent stressors and psychomotor stimulants) and kindling of seizures both provide clues to mechanisms in the progressive course of bipolar disorder.We describe aspects of bipolar illness that show sensitization and ...
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Methods for Modeling Early Life Stress in Rodents

Animal models of early life stress/adversity (ELS) have provided a foundation from which our understanding of the psychoneuroimmunology of childhood trauma has expanded over recent decades. Rodent models are a cornerstone of the ELS literature with many studies utilizing paradigms based on early life separation/deprivation protocols and manipulating ...
Jamie Y, Choe, Harlan P, Jones
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Telomeres and Early-Life Stress

2021
Stefanie Mayer   +3 more
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Early Life Stress and Development

2020
Tiffany Phu, Neda Senehi, Sarah Watamura
openaire   +1 more source

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