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Plasticity of the epigenome during early-life stress
Seminars in Cell & Developmental Biology, 2018Early life adversity remains a significant risk factor for the development of a host of negative behavioural and pathological outcomes in adulthood long after the stressor is over. Recent evidence indicates that these lasting effects of ELS may occur via alterations in the epigenetic landscape.
Burns, S. Barnett +4 more
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Early life stress in depression susceptibility
Science, 2017Neurodevelopment The linkage between stress early in life and behavioral depression in adulthood is complex. Pena et al. were able to define a time period in early development when mice are especially susceptible to stress. Mice subjected to stress during this time period were less resilient to stress in adulthood.
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Stress in early life inhibits neurogenesis in adulthood
Trends in Neurosciences, 2005Both structure and function of the hippocampus are altered by stress: by increasing levels of corticosteroids, stress causes atrophy of CA3 pyramidal cell dendrites, inhibits adult neurogenesis in the dentate gyrus, and impairs hippocampus-dependent learning.
Yashmin J G, Karten +2 more
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Early Adolescence as a Life Stress
1980Relationships between life stress and susceptibility to various physical and psychological disorders has been shown by many studies. These issues deserve careful study in early adolescence in particular. The concept of early adolescence is relatively new.
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Early Life Stress and Psychopathology
2018Exposure to chronic or severe stressful life events during childhood and adolescence—frequently referred to as early life stress (ELS) or childhood adversity—has powerful and lasting associations with psychopathology across the life course. This chapter reviews the growing body of research on ELS and psychopathology across the life course, with a ...
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Effects Of Stress In Early Life
2004Abstract International adoptees encounter stress both prenatally and postnatally (Table 8–1). Most are products of unwanted pregnancies. After birth, many suffer from abandonment, institutionalization, malnutrition, recurrent illnesses, environmental deprivation, and/or emotional neglect.
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The Kindling/Sensitization Model and Early Life Stress
2020Few animal models address the characteristics of the longitudinal course of bipolar disorder. However, behavioral sensitization (to recurrent stressors and psychomotor stimulants) and kindling of seizures both provide clues to mechanisms in the progressive course of bipolar disorder.We describe aspects of bipolar illness that show sensitization and ...
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Methods for Modeling Early Life Stress in Rodents
Animal models of early life stress/adversity (ELS) have provided a foundation from which our understanding of the psychoneuroimmunology of childhood trauma has expanded over recent decades. Rodent models are a cornerstone of the ELS literature with many studies utilizing paradigms based on early life separation/deprivation protocols and manipulating ...Jamie Y, Choe, Harlan P, Jones
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Early Life Stress and Development
2020Tiffany Phu, Neda Senehi, Sarah Watamura
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