Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Stress has been consistently linked to changes in eating behaviors and psychological well-being among adolescents and young adults, yet evidence remains fragmented regarding how gender, developmental stage, and psychological resources jointly shape these
Adelinda Araújo Candeias +2 more
doaj +1 more source
A Comparison of Information Technology Mediated Customer Services Between the U.S. and China [PDF]
Information technology mediated customer service is a reality of the 21st century. More and more companies have moved their customer services from in store and in person to online through computer or mobile devices. Using 442 responses collected from one
Behling, Robert +2 more
core +1 more source
Genetic analyses of sensory characteristics and relationships with fatty acid composition in the meat from Scottish Blackface lambs [PDF]
Genetic parameters for eating quality assessed by trained taste panellists were estimated on longissimus thoracis et lumborum (LTL) muscle in Scottish Blackface lambs, comprising lines previously divergently selected for carcass lean content (FAT and ...
Bishop, S. C. +4 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Actinidin is a cysteine protease enzyme which occurs in kiwifruit and has been associated with improved tenderness in red meat. This study evaluated the impact of actinidin, derived from kiwifruit, on consumer sensory outcomes for striploin (M ...
Angela Lees +4 more
doaj +1 more source
Are dogs that eat quickly more likely to develop a gastric dilatation (+/- volvulus) than dogs that eat slowly? [PDF]
The available evidence is mixed and of variable quality. Most evidence indicates that rate of eating has no effect on risk of gastric dilatation – volvulus (GDV). Where significant effects occur, fast eating was implicated as a risk factor.
Buckley, Louise
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The objective of this study was to determine the effects of silage plant species (faba bean and field pea based whole crop legume-cereals vs. grass) on performance and meat quality of growing Aberdeen Angus (AA) and Nordic Red (NR) bulls. A 2×3 factorial
Arto Kalevi Huuskonen +2 more
doaj +1 more source
Study protocol to investigate the effect of a lifestyle intervention on body weight, psychological health status and risk factors associated with disease recurrence in women recovering from breast cancer treatment [PDF]
Background Breast cancer survivors often encounter physiological and psychological problems related to their diagnosis and treatment that can influence long-term prognosis.
A Campbell +109 more
core +4 more sources

