Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents ...
Travis K Warren+61 more
semanticscholar +1 more source
Pre-Ebola virus disease laboratory system and related challenges in Liberia
Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of ...
Stephen B. Kennedy+7 more
doaj +1 more source
Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization. [PDF]
BACKGROUND: The recent West African Ebola epidemic led to accelerated efforts to test Ebola vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (VEBCON), we performed a phase I clinical trial investigating rVSV-ZEBOV (a ...
Addo, MM+22 more
core +1 more source
Increased Likelihood of Detecting Ebola Virus RNA in Semen by Using Sample Pelleting
Ebola virus RNA can reside for months or years in semen of survivors of Ebola virus disease and is probably associated with increased risk for cryptic sexual transmission of the virus.
Courtney M. Bozman+11 more
doaj +1 more source
Plant phenology supports the multi-emergence hypothesis for ebola spillover events [PDF]
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored.
Douglas, Noah E.+6 more
core +1 more source
Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon
An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus.
Jessica L. Abbate+4 more
doaj +1 more source
Exploiting the Reverse Vaccinology Approach to Design Novel Subunit Vaccine against Ebola Virus
Ebola virus is a highly pathogenic RNA virus that causes haemorrhagic fever in human. With very high mortality rate, Ebola virus is considered as one of the dangerous viruses in the world.
M. Ullah, Bishajit Sarkar, S. Islam
semanticscholar +1 more source
Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus
Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs.
Qinghua Cui+7 more
doaj +1 more source
Recommendations for dealing with waste contaminated with Ebola virus: a Hazard Analysis of Critical Control Points approach [PDF]
Objective To assess, within communities experiencing Ebola virus outbreaks, the risks associated with the disposal of human waste and to generate recommendations for mitigating such risks.
Ahmed A Mohamedani+25 more
core +2 more sources
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases
Significance Remdesivir is a nucleotide analog prodrug that has been evaluated in humans against acute Ebola virus disease; it also recently received emergency use authorization for treating COVID-19.
Michael K. Lo+17 more
semanticscholar +1 more source