Results 71 to 80 of about 1,757,150 (280)

A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

Nature Communications, 2019
There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Ebola virus (EBOV) infection.
M. Flint, P. Chatterjee, D. L. Lin, L. McMullan, P. Shrivastava-Ranjan, É. Bergeron, Michael K. Lo, S. R. Welch, S. Nichol, Andrew W. Tai, C. Spiropoulou   +10 more
semanticscholar   +1 more source

Relationship Between Knowledge and Compliance With Safety Measures: Evidence From COVID‐19

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Compliance with health safety protocols is important for protecting public health, particularly in agricultural sectors where disease outbreaks can disrupt production and market access. Despite its economic significance, we know little about what drives protocol compliance.
Nilufer Cetik, Carola Grebitus, Lauren Chenarides   +2 more
wiley   +1 more source

Ebola virus disease: past, present and future

Asian Pacific Journal of Tropical Biomedicine, 2015
Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate (up to 90%) accompanying with the disease. Ebola haemorrhagic fever (EHF) is an infectious disease of animal that can be transmitted to both human and ...
Harish Rajak, Deepak Kumar Jain, Avineesh Singh, Ajay Kumar Sharma, Anshuman Dixit   +4 more
doaj   +1 more source

Persistence of immunological memory as a potential correlate of long-term, vaccine-induced protection against Ebola virus disease in humans

Frontiers in Immunology, 2023
IntroductionIn the absence of clinical efficacy data, vaccine protective effect can be extrapolated from animals to humans, using an immunological biomarker in humans that correlates with protection in animals, in a statistical approach called ...
Chelsea McLean, Karin Dijkman, Auguste Gaddah, Babajide Keshinro, Michael Katwere, Macaya Douoguih, Cynthia Robinson, Laura Solforosi, Dominika Czapska-Casey, Liesbeth Dekking, Yvonne Wollmann, Ariane Volkmann, Maria Grazia Pau, Benoit Callendret, Jerry Sadoff, Hanneke Schuitemaker, Roland Zahn, Kerstin Luhn, Jenny Hendriks, Ramon Roozendaal   +19 more
doaj   +1 more source

Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

Journal of Infectious Diseases, 2018
Background For most classes of drugs, rapid development of therapeutics to treat emerging infections is challenged by the timelines needed to identify compounds with the desired efficacy, safety, and pharmacokinetic profiles.
Kristen E. Pascal, Drew Dudgeon, John C. Trefry, Manu Anantpadma, Yasuteru Sakurai, C. D. Murin, H. Turner, J. Fairhurst, Marcela Torres, A. Rafique, Ying Yan, A. Badithe, Kevin Yu, Terra Potocky, S. Bixler, Taylor B. Chance, W. Pratt, Franco D. Rossi, J. Shamblin, S. Wollen, Justine M. Zelko, R. Carrion, Gabriella Worwa, Hilary M Staples, D. Burakov, R. Babb, Gang Chen, Joel Martin, Tammy Huang, Karl J. Erlandson, Melissa S Willis, Kimberly L. Armstrong, T. Dreier, A. Ward, R. Davey, M. Pitt, L. Lipsich, P. Mason, W. Olson, N. Stahl, C. Kyratsous   +40 more
semanticscholar   +1 more source

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

BMEMat, EarlyView.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li, Huaijuan Zhou, Di Shi, Zdeněk Sofer, Jinhua Li   +4 more
wiley   +1 more source

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

Cell Discovery, 2018
The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need.
Shu Yang, Miao Xu, Emily M. Lee, Kirill Gorshkov, S. Shiryaev, Shihua He, Wei Sun, Yu‐Shan Cheng, Xin Hu, Anil M. Tharappel, Billy Lu, Antonella Pinto, Chen Farhy, Chun-Teng Huang, Zirui Zhang, Wenjun Zhu, Yuying Wu, Yi Zhou, Guang Song, Heng Zhu, K. Shamim, Carles Martínez-Romero, A. García-Sastre, R. Preston, D. Jayaweera, Ruili Huang, Wenwei Huang, M. Xia, A. Simeonov, G. Ming, X. Qiu, A. Terskikh, Hengli Tang, Hongjun Song, Wei Zheng   +34 more
semanticscholar   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, EarlyView.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Calcium ions directly interact with the Ebola virus fusion peptide to promote structure-function changes that enhance infection.

ACS Infectious Diseases, 2019
Ebola virus disease is a serious global health concern given its periodic occurrence, high lethality, and the lack of approved therapeutics. Certain drugs that alter intracellular calcium, particularly in endo-lysosomes, have been shown to inhibit Ebola ...
Lakshmi Nathan, A. Lai, J. Millet, Marco R. Straus, J. Freed, G. Whittaker, S. Daniel   +6 more
semanticscholar   +1 more source

Sequence‐Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides

ChemistryEurope, EarlyView.
Two oppositely charged intrinsically disordered peptides (IDPs) coassemble into heterotypic nanofibers. Homochiral mixtures (L/L IDPs) form homogeneous, aligned bundles with the more positive IDP. Heterochiral mixtures (L/D IDPs) yield heterogeneous, twisted bundles as positive‐IDP content increases.
Yuchen Qiao, Matthew Chu, Grace Wu, Zhiyu Liu, Bing Xu   +4 more
wiley   +1 more source