Re-emergence of Sudan ebolavirus after a decade: new challenge to Ebola control
International Journal of Surgery, 2023 Dear Editor, Outbreaks of African filoviruses often have resulted into high mortality, and of these, the West Africa Ebola outbreak during 2014–2016 accounted for more than 11 000 deaths among around 28 000 cases.
R. Sah +8 more
semanticscholar +1 more source
Presence and persistence of Ebola or Marburg virus in patients and survivors: A rapid systematic review [PDF]
, 2016 Background: The 2013-15 Ebola outbreak was unprecedented due to sustainedtransmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance ...
Brainard, Julii +4 more
core +3 more sources
Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
core +2 more sources
Taï Forest Virus Does Not Cause Lethal Disease in Ferrets
Microorganisms, 2021 Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates.
Zachary Schiffman +8 more
doaj +1 more source
Plant phenology supports the multi-emergence hypothesis for ebola spillover events [PDF]
, 2017 Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored.
Douglas, Noah E. +6 more
core +1 more source
Ebolavirus Evolution: Past and Present
PLOS Pathogens, 2015 The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time.
Marc-Antoine de La Vega +2 more
openaire +5 more sources
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The membrane fusion proteins of viral pathogens as diverse in their replication strategies as coronaviruses and filoviruses depend, for their functional activity, on proteolytic processing during cell entry.
Yuan-Lin Kang +10 more
semanticscholar +2 more sources
Tenacious Researchers Identify a Weakness in All Ebolaviruses. [PDF]
, 2018 The Ebolavirus genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive.
DuBois, Rebecca M
core +1 more source
rVSV-ZEBOV vaccination in people with pre-existing immunity to Ebolavirus: an open-label safety and immunogenicity study in Guinean communities affected by Ebola virus disease (l'essai proches). [PDF]
BMC MedZaire Ebolavirus disease (EVD) outbreaks can be controlled using rVSV-ZEBOV vaccination and other public health measures. People in high-risk areas may have pre-existing antibodies from asymptomatic Ebolavirus exposure that might affect response to rVSV ...
Watson CH +36 more
europepmc +2 more sources
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source