Results 61 to 70 of about 12,924 (266)
Tenacious Researchers Identify a Weakness in All Ebolaviruses. [PDF]
, 2018 The Ebolavirus genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive.
DuBois, Rebecca M
core +1 more source
VP24-Karyopherin alpha binding affinities differ between Ebolavirus species, nfluencing interferon inhibition and VP24 stability [PDF]
, 2017 Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV), and Reston ebolavirus (RESTV) belong to the same genus but exhibit different virulence properties.
Alinger, Joshua B +6 more
core +2 more sources
Nature Communications, 2022 Virus infection affects cellular proteostasis and provides an opportunity to study this cellular process under perturbation. The proteostasis network in the endoplasmic reticulum (ER) is composed of the calnexin cycle, and the two protein degradation ...
J. Zhang +7 more
semanticscholar +1 more source
Ebolavirus and Haemorrhagic Syndrome
Sultan Qaboos University Medical Journal, 2015 The Ebola virus is a highly virulent, single-stranded ribonucleic acid virus which affects both humans and apes and has fast become one of the world's most feared pathogens. The virus induces acute fever and death, with haemorrhagic syndrome occurring in up to 90% of patients.
Gerald A. Matua +2 more
openaire +4 more sources
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Emerging Microbes and Infections, 2022 Ebolaviruses cause outbreaks of haemorrhagic fever in Central and West Africa. Some members of this genus such as Ebola virus (EBOV) are highly pathogenic, with case fatality rates of up to 90%, whereas others such as Reston virus (RESTV) are apathogenic
B. Bodmer +15 more
semanticscholar +1 more source
Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations
Problems of Virology, 2021 Ebola virus disease (EVD) (former Ebola hemorrhagic fever) is one of the most dangerous infectious diseases affecting humans and primates. Since the identification of the first outbreak in 1976, there have been more than 25 outbreaks worldwide, the largest of which escalated into an epidemic in 2014-2016 and caused the death of more than 11,000 people.
I. V. Dolzhikova +3 more
openaire +5 more sources
Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak [PDF]
, 2015 The 2014 epidemic of Ebola virus disease (EVD) has had a devastating impact in West Africa. Sequencing of ebolavirus (EBOV) from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to ...
Jiang, Xiaowei +3 more
core +1 more source
Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region
PLoS Pathogens, 2022 The three human pathogenic ebolaviruses: Zaire (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) virus, cause severe disease with high fatality rates. Epitopes of ebolavirus glycoprotein (GP) recognized by antibodies with binding breadth for all three ...
Clara T. Schoeder +19 more
semanticscholar +1 more source
Discovery of an antibody for pan-ebolavirus therapy [PDF]
Scientific Reports, 2016 AbstractDuring the latest outbreak of Ebola virus disease in West Africa, monoclonal antibody therapy (e.g., ZMapp) was utilized to treat patients. However, due to the antigenic differences among the five ebolavirus species, the current therapeutic monoclonal antibodies are only effective against viruses of the species Zaire ebolavirus.
Furuyama, Wakako +10 more
openaire +8 more sources