Results 61 to 70 of about 11,443 (200)

Immunogenicity and safety of Ebola virus vaccines in healthy adults: a systematic review and network meta-analysis

Human Vaccines & Immunotherapeutics, 2021
Clinical development of Ebola virus vaccines (EVV) was accelerated by the West African Ebola virus epidemic which remains the deadliest in history. To compare and rank the EVV according to their immunogenicity and safety.
Alhassane Diallo, Miguel Carlos-Bolumbu, Minerva Cervantes-Gonzalez, Veronika Wozniak, Mamadou Hassimiou Diallo, Boubacar Djelo Diallo, Alexandre Delamou, Florence Galtier   +7 more
doaj   +1 more source

Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma

Frontiers in Immunology, 2021
Three clinically relevant ebolaviruses – Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa.
Pavlo Gilchuk, Adrian Guthals, Stefano R. Bonissone, Jared B. Shaw, Philipp A. Ilinykh, Philipp A. Ilinykh, Kai Huang, Kai Huang, Robin G. Bombardi, Jenny Liang, Ariadna Grinyo, Edgar Davidson, Elaine C. Chen, Bronwyn M. Gunn, Galit Alter, Erica Ollmann Saphire, Benjamin J. Doranz, Alexander Bukreyev, Alexander Bukreyev, Alexander Bukreyev, Larry Zeitlin, Natalie Castellana, James E. Crowe, James E. Crowe, James E. Crowe   +24 more
doaj   +1 more source

Ebolavirus vaccines for humans and apes [PDF]

Current Opinion in Virology, 2012
Because of high case fatality proportions, person-to-person transmission, and potential use in bioterrorism, the development of a vaccine against ebolavirus remains a top priority. Although no licensed vaccine or treatment against ebolavirus is currently available, progress in preclinical testing of countermeasures has been made.
Hugues, Fausther-Bovendo, Sabue, Mulangu, Nancy J, Sullivan   +2 more
openaire   +2 more sources

Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two‐Sample Mendelian Randomization Study Based on European Ancestry

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Objective This study employed Mendelian randomization (MR) to investigate the causal relationships between 4907 circulating proteins and hyperlipidemia, with the aim of identifying potential drug targets. Methods Instrumental variables were derived from genome‐wide association study (GWAS) data on 4907 circulating proteins ...
Hui Cheng, Dayuan Zhong
wiley   +1 more source

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor

MedComm, Volume 6, Issue 9, September 2025.
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang, Huiqiang Wang, Shuo Wu, Ge Yang, Haiyan Yan, Lijun Qiao, Xingqiong Li, Mengyuan Wu, Jiandong Jiang, Yuhuan Li   +9 more
wiley   +1 more source

High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo [PDF]

, 2016
Background Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub- Saharan Africa.
Afounde, Afongenda, Borchert, Matthias, Kulidri, Amayo, Mulangu, Sabue, Muyembe-Tamfum, Jean-Jacques, Paweska, Janusz, Swanepoel, Robert, Tshomba, Antoine, Van der Stuyft, Patrick   +8 more
core   +1 more source

Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors. [PDF]

, 2016
Robust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of immunity is poorly understood.
Cose, Stephen, Dye, John M, Egesa, Moses, Eskira, Yael, Fedida-Metula, Shlomit, Herbert, Andrew S, Kuehne, Ana I, Lewis, Eli C, Lobel, Leslie, Lutwama, Julius Julian, Ochayon, David E, Sobarzo, Ariel, Stonier, Spencer W, Tali, Neta, Yavelsky, Victoria   +14 more
core   +2 more sources

Virological diagnosis of Ebolavirus infection

Pathology, 2015
Ebolaviruses, and the other viral causes of haemorrhagic fevers (VHF) have always posed special problems for diagnostic laboratories. These arise from the rarity of human infections, minimal documented experience with test delivery and interpretation, the paucity of established commercial or in-house assays, the lack of clinical material for test ...
Smith, D.W., Rawlinson, W.D., Kok, J., Dwyer, D.E., Catton, M.   +4 more
openaire   +2 more sources

Characterization of Ebolavirus regulatory genomic regions [PDF]

Virus Research, 2009
For filoviruses, such as Ebolavirus and the closely related Marburgvirus, transcriptional regulation is poorly understood. The open reading frames (ORFs) that encode the viral proteins are separated by regulatory regions composed of the 3' nontranslated region (NTR) of the upstream gene, highly conserved transcription stop and start signals, and the 5 ...
Gabriele, Neumann, Shinji, Watanabe, Yoshihiro, Kawaoka   +2 more
openaire   +2 more sources

Mapping the Potential Risk of Coronavirus Spillovers in a Global Hotspot

Global Change Biology, Volume 31, Issue 9, September 2025.
Bats host a vast array of viruses, including those behind SARS and COVID‐19. This study maps coronavirus spillover risk hotspots across South and Southeast Asia by combining horseshoe bat species distributions, forest fragmentation, and human population density.
R. Sedricke Lapuz, Ada Chornelia, Alice C. Hughes   +2 more
wiley   +1 more source