Results 11 to 20 of about 125,177 (307)

Immune defence against EBV and EBV-associated disease

Current Opinion in Immunology, 2011
Epstein-Barr virus (EBV), a B-lymphotropic herpesvirus widespread in the human population and normally contained as an asymptomatic infection by T cell surveillance, nevertheless causes infectious mononucleosis and is strongly linked to several types of human cancer. Here we describe new findings on the range of cellular immune responses induced by EBV
Heather M, Long, Graham S, Taylor, Alan B, Rickinson   +2 more
openaire   +3 more sources

Integrated Multiomic Analysis Reveals an EBV-Associated MIF-SPP1⁺ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma. [PDF]

Adv Sci (Weinh)
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Liu GY, Lv SH, He SQ, Jiang YF, Peng XS, Sun JC, He F, Qin HY, Lu N, Bei WX, Zhao LY, Shen WQ, Zhao ZY, Wang L, Xiang YQ, Li WZ.   +15 more
europepmc   +2 more sources

EBV and Lymphomagenesis

Cancers, 2023
The clinical significance of Epstein–Barr virus (EBV) cannot be understated. Not only does it infect approximately 90% of the world’s population, but it is also associated with numerous pathologies. Diseases linked to this virus include hematologic malignancies such as diffuse large B-cell lymphoma, Hodgkin lymphoma, Burkitt lymphoma, primary CNS ...
Sausen, Daniel G., Basith, Ayeman, Muqeemuddin, Syed   +2 more
openaire   +2 more sources

Antiviral Drugs for EBV [PDF]

Cancers, 2018
Epstein–Barr virus (EBV) infects up to 95% of the adult human population, with primary infection typically occurring during childhood and usually asymptomatic. However, EBV can cause infectious mononucleosis in approximately 35–50% cases when infection occurs during adolescence and early adulthood.
Pagano, Joseph S., Whitehurst, Christopher B., Andrei, Graciela   +2 more
openaire   +3 more sources

Progress in EBV Vaccines [PDF]

Frontiers in Oncology, 2019
The Epstein-Barr virus (EBV) is a ubiquitous pathogen that imparts a significant burden of disease on the human population. EBV is the primary cause of infectious mononucleosis and is etiologically linked to the development of numerous malignancies.
Dwain G. van Zyl, Dwain G. van Zyl, Dwain G. van Zyl, Josef Mautner, Josef Mautner, Henri-Jacques Delecluse, Henri-Jacques Delecluse, Henri-Jacques Delecluse   +7 more
openaire   +4 more sources

Transplantation immunology: aspects of allo- and EBV-specific reactivity : the EBV non-infected elderly - factors of resistance [PDF]

, 2010
Defining the relevant components of cellular alloimmunity remains an important unresolved issue in clinical transplantation. The most promising marker of cellular alloreactivity available to date is donor-specific secretion of interferon-gamma (IFN-) as ...
Durovic, Bojana
core   +1 more source

EBV and Lymphomagenesis

Uirusu, 2019
Epstein-Barr virus (EBV) is a double stranded DNA virus of the family Herpesviridae. EBV is associated with a variety of lymphomas, and the mechanisms by which it promotes lymphomagenesis have been elucidated; this includes, for example, by translocation/activation of Myc in Burkitt lymphoma.
Hiroshi, Kimura, Yusuke, Okuno
openaire   +3 more sources

Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy. [PDF]

, 2007
Epstein-Barr virus (EBV) is associated with a number of human malignancies. EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive transfer ...
Burdach, S., Witter, K., Boerschmann Heike, Boerschmann, H., Mautner, Josef, Georg W Bornkamm, Adhikary, D., Adhikary, Dinesh, Uta Behrends, Burdach Stefan, Bornkamm, G.W., Mautner, J., Georg W, Andrea Pfünder, Moosmann, A., Witter Klaus, Adhikary Dinesh, Pfünder, Andrea, Dinesh Adhikary, Klaus Witter, Pfünder Andrea, Josef Mautner, Behrends Uta, Stefan Burdach, Moosmann Andreas, Andreas Moosmann, Bornkamm Georg W., Behrends, Uta, Boerschmann, Heike, Burdach, Stefan, Bornkamm, Georg W., Pfünder, A., Witter, Klaus, Behrends, U., Mautner Josef, Moosmann, Andreas, Heike Boerschmann, Adhikary, D;Behrends, U;Boerschmann, H;Pfünder, A;Burdach, S;Moosmann, A;Witter, K;Bornkamm, GW;Mautner, J, Georg W. Bornkamm   +38 more
core   +1 more source

fircothep262/ebv-msi-detection-by-dl: v1.0.0

, 2021
Full Changelog: https://github.com/fircothep262/ebv-msi-detection-by-dl/commits/v1.0.
fircothep262
core   +1 more source

EBV CHRONIC INFECTIONS

Mediterranean Journal of Hematology and Infectious Diseases, 2010
The infection from Epstein-Barr virus (EBV) or virus of infectious mononucleosis, together with other herpesviruses’ infections, represents a prototype of persistent viral infections characterized by the property of the latency. Although the reactivations of the latent infection are associated with the resumption of the viral replication and eventually
PIZZIGALLO, Eligio, Racciatti D, Gorgoretti V.   +2 more
openaire   +6 more sources