Results 191 to 197 of about 12,362 (197)

In vitro activity of a Hos2 deacetylase inhibitor, MGCD290, in combination with echinocandins against echinocandin-resistant Candida species

Diagnostic Microbiology and Infectious Disease, 2015
MGCD290, a Hos2 fungal histone deacetylase inhibitor, showed modest activity when tested alone (MIC range, 0.12-4 μg/mL; MIC50/90, 0.5/4 μg/mL) against Candida glabrata (n=15; 14 fks mutants; 5 also fluconazole resistant), Candida albicans (8 fks mutants; 2 also fluconazole resistant), Candida tropicalis (4 fks mutants), and Candida krusei (3 fks ...
M A, Pfaller, P R, Rhomberg, S A, Messer, M, Castanheira   +3 more
openaire   +2 more sources

Echinocandin Antifungal Drug Resistance in Candida Species: A Cause for Concern?

Current Infectious Disease Reports, 2010
The echinocandins, the newest generation of antifungal agents, are inhibitors of β-1,3-D-glucan synthesis, an action that damages fungal cell walls. Despite a relatively broad spectrum of activity, these drugs are rapidly fungicidal against most Candida spp and have established noninferiority over existing antifungal drugs in the treatment of invasive ...
Sanguinetti, Maurizio, Posteraro, P, Posteraro, Brunella   +2 more
openaire   +4 more sources

Echinocandin Resistance in Candida Species: a Review of Recent Developments

Current Infectious Disease Reports, 2016
The echinocandins are important agents for the treatment of invasive fungal infections, especially those caused by Candida species. However, as with other antimicrobial agents, microbiologic resistance to this class of antifungal agents has emerged and can result in clinical failure.
openaire   +2 more sources

Echinocandin Resistance

2017
openaire   +1 more source

P1966 FKS mutation in echinocandin-resistant C. glabrata

International Journal of Antimicrobial Agents, 2007
K.J. Dodgson, B. Kaur, A.Y. Sharafadein, S.A. Messer, M.A. Pfaller, A.R. Dodgson   +5 more
openaire   +1 more source

Echinocandins: Exploring Susceptibility and Resistance

2009
openaire   +1 more source

Echinocandin-resistant Candida albicans: A case report from Japan

Journal of Infection and Chemotherapy
Sayaka Hikida, Yutaro Akiyama, Masahiro Ishikane, Hiroshi Shimazu, Ryo Nasu, Takayuki Shinohara, Minoru Nagi, Rei Shirai, Makiko Onakado, Nobuko Nakayama, Yoshitsugu Miyazaki, Akira Hangaishi, Norio Ohmagari   +12 more
openaire   +1 more source