Results 141 to 150 of about 730 (160)

7-Ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone (echinochrome A): A DFT study of the antioxidant mechanism. 1. Interaction of echinochrome A with hydroperoxyl radical

Russian Chemical Bulletin, 2007
The molecular geometry and electronic structure of hydroxy-substituted naphthazarin (NZ)-7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone (echinochrome A, (Et)NZ(β-OH)3, 1) were calculated by the B3LYP/6-311G(d) method. The influence of the (i) character of the β-OH groups dissociation and (ii) conformational mobility of molecule 1 and the anions ...
D. V. Berdyshev, V. P. Glazunov, V. L. Novikov   +2 more
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Effect of Antioxidant Echinochrome A on Bleomycin-Induced Pulmonary Fibrosis

Bulletin of Experimental Biology and Medicine, 2015
We studied the protective effect of antioxidant echinochrome A on bleomycin-induced pulmonary fibrosis in rats at the early stages of postnatal ontogeny. Administration of echinochrome A was shown to reduce the severity of bleomycin-induced oxidative stress in the lungs, prevented the development of hypertrophy of interalveolar connective tissue and ...
O A, Lebed'ko, B Ya, Ryzhavskii, O V, Demidova   +2 more
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A simple new bioassay based on echinochrome synthesis by larval sea urchins

Marine Environmental Research, 1983
Abstract A simple, rapid and quantitative embryo-larval bioassay that uses changes in echinochrome pigment synthesis as an indicator of seawater toxicity has been developed to allow increased use of sensitive sea urchin bioassays where time, resources and technical expertise may be limited. Several 48 h embryo-larval tests were conducted with lowered
Steven M. Bay, Philip S. Oshida, Kenneth D. Jenkins   +2 more
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Comparative In Vitro Study of Antiherpetic Activity of Echinochrome A and Product of Its Oxidation Dehydroechinochrome

Bulletin of Experimental Biology and Medicine, 2021
The quinoid pigment echinochrome A isolated from the sea urchin Scaphechinus mirabilis, the product of its oxidation dehydroechinochrome, and structurally similar antiviral agent oxolin were tested for their ability to inhibit plaque formation induced by herpes simplex virus type 1 (HSV-1) in Vero cells. The tested compounds showed significant anti-HSV-
O V, Iunikhina, N V, Krylova, N P, Mishchenko, E A, Vasileva, S A, Fedoreyev, M Yu, Shchelkanov   +5 more
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Echinochrome-A as a bactericidal substance in the coelomic fluid of Echinus esculentus (L.)

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1984
Abstract 1. 1. The concentrations of echinochrome-A in coelomic fluid from healthy specimens of the sea urchin Echinus esculentus (L.) ranged from 3 to 60 μg/ml, with a geometric mean of 14 μg/ml. 2. 2. Echinochrome-A (50 μg/ml) dissolved in sea water, with the aid of mammalian proteins as dispersants, was bactericidal or bacteriostatic ...
Matthew Service, Alastair C. Wardlaw
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Antioxidant Properties, Autooxidation, and Mutagenic Activity of Echinochrome A Compared with Its Etherified Derivative

Biochemistry (Moscow), 2001
Antioxidant properties of 2,3,5,7,8-pentahydroxy-6-ethyl-1,4-naphthoquinone (echinochrome A) were linked with the scavenging of peroxy radicals in liposomes, trapping of superoxide anion radicals, and binding of ferrous ions to inactive complexes in the aqueous phase. The antioxidant property of 6-ethyl-2,3,7-trimethoxy-5,8-dihydroxy-1,4-naphthoquinone
A V, Lebedev, E L, Levitskaya, E V, Tikhonova, M V, Ivanova   +3 more
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Pharmacological activity of echinochrome a alone and in the biologically active additive Timarin

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2013
Pharmacological activity of echinochrome A (EchA) alone and in the biologically active additives (BAA) Timarin, administered per os has been investigated in volunteers. Blood hematological, immunological, and biochemical parameters were investigated before and after administration of the substances used.
A. A. Artyukov, A. M. Popov, A. V. Tsybulsky, O. N. Krivoshapko, N. V. Polyakova   +4 more
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Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca2+ reuptake

Pflügers Archiv - European Journal of Physiology, 2014
Echinochrome A (Ech A), a marine bio-product isolated from sea urchin eggs, is known to have cardioprotective effects through its strong antioxidant and ATP-sparing capabilities. However, the effects of Ech A on cardiac excitation–contraction (E-C) are not known.
Hyoung Kyu Kim, Jae Boum Youm, Seung Hun Jeong, Sung Ryul Lee, In-Sung Song, Tae Hee Ko, Julius Ryan Pronto, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Bernd Nilius, Natalia P. Mischchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +14 more
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27459 Protection potential of echinochrome A on UV damaged skin

Journal of the American Academy of Dermatology, 2021
Seong Min Hong, Sang Woo Ahn, Jong Uk Kim, Gyeong Je Cho, Woo Jung Jin, So Hee Park, Jin Han, Hyojin Kim, Jung Eun Seol   +8 more
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Electron capture mass spectrometry of echinochrome A

Journal of Analytical Chemistry, 2011
Yu. N. El’kin, A. I. Cherednichenko, E. A. Kol’tsova, A. A. Artyukov   +3 more
openaire   +1 more source