Frontiers in Physiology, 2020 Tooth agenesis is one of the most common orodental anomalies that demonstrate phenotypic and genotypic heterogeneity with a prevalence of 2.5%–7%. Mutations in WNT10A have been proposed to be the most common cause of nonsyndromic tooth agenesis (NSTA ...
Charinya Kanchanasevee +8 more
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Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. [PDF]
PLoS ONE, 2015 In recent years, several studies have shed light into the processes that regulate epidermal specification and homeostasis. We previously showed that a broad-spectrum γ-secretase inhibitor DAPT promoted early keratinocyte specification in human embryonic ...
Ana Mafalda Baptista Tadeu +6 more
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A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis
BMC Biology, 2018 Background The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm.
Santosh Kumar Maharana +1 more
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Role of Smad4 from ocular surface ectoderm in retinal vasculature development [PDF]
International Journal of Ophthalmology, 2020 "AIM: To investigate how signals from lens regulate retinal vascular development and neovascularization. METHODS: Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively.
Jing Li +3 more
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Ancestral regulatory circuits governing ectoderm patterning downstream of Nodal and BMP2/4 revealed by gene regulatory network analysis in an echinoderm. [PDF]
PLoS Genetics, 2010 Echinoderms, which are phylogenetically related to vertebrates and produce large numbers of transparent embryos that can be experimentally manipulated, offer many advantages for the analysis of the gene regulatory networks (GRN) regulating germ layer ...
Alexandra Saudemont +12 more
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Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2022 Introduction: Long non-coding RNAs (lncRNAs) and miRNAs belong to a class of non-coding RNAs (ncRNAs) that play important roles and functions in the regulation of the expression of genes in main biological processes, such as cell proliferation, apoptosis,
Somayeh Moghaddam, Esmaeil Babaei
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eLife, 2016 The mechanisms that underlie directional cell migration are incompletely understood. Eph receptors usually guide migrations of cells by exclusion from regions expressing Ephrin.
Oliver A Krupke +3 more
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Manipulation of cell:cell contacts and mesoderm suppressing activity direct lineage choice from pluripotent primitive ectoderm-like cells in culture. [PDF]
PLoS ONE, 2009 In the mammal, the pluripotent cells of embryo differentiate and commit to either the mesoderm/endoderm lineages or the ectoderm lineage during gastrulation.
James N Hughes +6 more
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BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm
Stem Cell Research, 2015 During embryonic development, oral ectoderm differentiates into the adenohypophysis, dental epithelia, salivary glands, and nasal pit. Few reports exist concerning the induction of oral ectoderm from embryonic stem (ES) cells.
Hiroshi Ochiai +12 more
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Requirement of Smad4 from Ocular Surface Ectoderm for Retinal Development. [PDF]
PLoS ONE, 2016 Microphthalmia is characterized by abnormally small eyes and usually retinal dysplasia, accounting for up to 11% of the blindness in children. Right now there is no effective treatment for the disease, and the underlying mechanisms, especially how ...
Jing Li +10 more
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