Results 91 to 100 of about 13,941 (262)

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

A Prevalence Study on Ectopic Calcification in Digital Panoramic Radiographs in Shahid Sadoughi Dental School of Yazd in 2012-2013

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2013
Introduction: soft tissue calcification is a relatively common issue in panoramic radiography. These opacities include calcification of lymph nodes, tonsilolith, sialolith, calcification of stylohyoid complex and carotid artery bifurcation.
Kh Kheirollahi, H Kheirollahi, F Ezoddini   +2 more
doaj  

Endothelial Fam20a Loss Drives Pulp Calcification Via Calcium-Dysregulated Paracrine

International Dental Journal
Aim or purpose: To elucidate the molecular mechanism of FAM20A deficiency in driving pathological Pulp Calcification (PC) and identify novel therapeutic targets for Enamel Renal Syndrome (ERS).
Changrong Tong, Ying Li, Bin Zhang, Han Jin, Yunfeng Wang, Wenxuan Zhang, Qiang Chen, Jingtong Tan, Fangping Zhang, Guixin Li   +9 more
doaj   +1 more source

ECTOPIC CALCIFICATION IN THE LUNG IN THE PATIENT ON LONG-TERM HEMODIALYSIS: REPORT OF A CASE [PDF]

, 1980
41 year old man developed ectopic calcification in the right lung while on the long-term hemodialysis. He has been on hemodialysis because of chronic renal failure for nine years.
細川, 進一, 友吉, 唯夫, 西尾, 利二, 長尾, 昌寿   +3 more
core  

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

Lysyl Oxidase in Ectopic Cardiovascular Calcification : Role of Oxidative Stress [PDF]

Lysyl oxidase (LOX)-mediated extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease; however, this enzyme also induces oxidative stress.
Laia Cañes, Ballester Servera, Carmen, Paula Vázquez-Sufuentes, Carme Ballester-Servera, Cristina Rodríguez, Ana B. García-Redondo, Rodríguez, Cristina, Martínez-González, José, Ballester-Servera, Carme, Vázquez-Sufuentes, Paula, Alonso Nieto, Judith, Alonso, Judith, Judith Alonso, Cañes, Laia, Garcia Redondo, Ana B.., Vázquez Sufuentes, Paula, Universitat Autònoma de Barcelona, José Martínez-González, García Redondo, Ana Belén, Cañes Esteve, Laia   +19 more
core   +3 more sources

Spectrum of Congenital Anomalies in Myhre Syndrome—Insights Into Effects Brought by Altered TGF‐β Signaling via Gain‐of‐Function Variants in SMAD4

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is a rare genetic disorder characterized by progressive multisystem involvement. Gain‐of‐function missense heterozygous variants affecting the Ile500 residue and Arg496 residue of the SMAD4 gene are implicated in this condition.
Kawmadi Gunawardena, Alessandro De Falco, Deborah Osio, Eleanor Sherlock, Emma Kivuva, Erina Sasaki, Francis H. Sansbury, Nayana Lahiri, Patricia Foley, Sahar Mansour, Shane McKee, Tazeen Ashraf, Nicola Brunetti‐Pierri, Usha Kini   +13 more
wiley   +1 more source

Cell Phenotype Transitions in Cardiovascular Calcification

Frontiers in Cardiovascular Medicine, 2018
Cardiovascular calcification was originally considered a passive, degenerative process, however with the advance of cellular and molecular biology techniques it is now appreciated that ectopic calcification is an active biological process.
Luis Hortells, Swastika Sur, Cynthia St. Hilaire   +2 more
doaj   +1 more source