Results 91 to 100 of about 139,269 (266)

Mechanisms of ectopic calcification: implications for diabetic vasculopathy. [PDF]

Cardiovasc Diagn Ther, 2015
Vascular calcification (VC) is the deposition of calcium/phosphate in the vasculature, which portends a worse clinical outcome and predicts major adverse cardiovascular events. VC is an active process initiated and regulated via a variety of molecular signalling pathways. There are mainly two types of calcifications: the media VC and the intima VC. All
Avogaro A, Fadini GP.
europepmc   +3 more sources

Cutaneous ectopic breast calcification in a haemodialysis patient

The Breast, 2003
This case report details the unique breast calcification and swellings of a 61-year-old lady. The ectopic breast calcification was a result of chronic renal failure and hyperparathyroidism secondary to vesiculo-ureteric reflux nephropathy. Subcutaneous nodules were also noted around her ileostomy (from surgery due to Crohn's disease) and abdominal wall.
T E, Cowlam, T E, Bucknall
openaire   +2 more sources

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

A Prevalence Study on Ectopic Calcification in Digital Panoramic Radiographs in Shahid Sadoughi Dental School of Yazd in 2012-2013

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2013
Introduction: soft tissue calcification is a relatively common issue in panoramic radiography. These opacities include calcification of lymph nodes, tonsilolith, sialolith, calcification of stylohyoid complex and carotid artery bifurcation.
Kh Kheirollahi, H Kheirollahi, F Ezoddini   +2 more
doaj  

2024 Annual Meeting of the International Network on Ectopic Calcification (INTEC)—Abstract Proceedings

The 3rd Annual Meeting of the International Network on Ectopic Calcification (INTEC) was held in Faro, Portugal on 12–13 September 2024. This hybrid meeting brought together researchers and clinicians focused on the molecular, (patho)physiological,
Camacho, Antonio, Derudder, Robbe, Arun-Kumar Kaliya-Perumal, Monzur Murshed, M. Leonor Cancela, Harris, Matthew P., Cancela, M. Leonor, Antonio Camacho, Yves Sabbagh, Elena Seminari, Marcos M. Villar, Qin, Zihan, Lengyel, Imre, Seminari, Elena, Antonella Forlino, Bertelli, Pietro M., Pietro M. Bertelli, Jacinto, Marta, Vanakker, Olivier M., Olivier M. Vanakker, Zihan Qin, Matthew P. Harris, Wolfgang Link, Alouane, Ahmed, Murshed, Monzur, Ahmed Alouane, Andreas Pasch, Link, Wolfgang, Villar, Marcos M., Forlino, Antonella, Pasch, Andreas, Winkler, Christoph, Robbe Derudder, Marta Jacinto, Sabbagh, Yves, Imre Lengyel, Kaliya-Perumal, Arun-Kumar, Quaglino, Daniela, Daniela Quaglino, Christoph Winkler, Vanakker, Olivier   +40 more
core   +1 more source

Targeting TREM2 signaling shows limited impact on cerebrovascular calcification [PDF]

Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and a diagnostic criterion for primary familial brain calcification.
Ibrahim, Adiljan, Colonna, Marco, Keller, Annika; id_orcid, Keller, Annika, Huang, Sheng-Fu, Zhou, Yingyue, Bertazzo, Sergio, Wyss, Tania, Swain, Amanda, Sridhar, Sucheta, Maheshwari, Upasana, Wyss, Tania; https://orcid.org/, Bertazzo, Sergio; https://orcid.org/, Colonna, Marco; https://orcid.org/, Maheshwari, Upasana; https://orcid.org/, Zhou, Yingyue; https://orcid.org/, Sridhar, Sucheta; https://orcid.org/, Keller, Annika; https://orcid.org/, Huang, Sheng-Fu; https://orcid.org/   +18 more
core   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Endothelial Fam20a Loss Drives Pulp Calcification Via Calcium-Dysregulated Paracrine

International Dental Journal
Aim or purpose: To elucidate the molecular mechanism of FAM20A deficiency in driving pathological Pulp Calcification (PC) and identify novel therapeutic targets for Enamel Renal Syndrome (ERS).
Changrong Tong, Ying Li, Bin Zhang, Han Jin, Yunfeng Wang, Wenxuan Zhang, Qiang Chen, Jingtong Tan, Fangping Zhang, Guixin Li   +9 more
doaj   +1 more source

Ectopic calcification and bone : a comparison of the effect of dietary carbohydrates, sugars and protein

, 2014
A number of studies have shown that severe calcification of the arteries, heart and kidneys commonly coexists withosteoporosis, particularly in renal disease.
Nicoll, Rachel, McLaren Howard, John, Henein, Michael Y,, Henein, Michael Y, Nicoll, Rachel,   +4 more
core   +1 more source

Ectopic calcification in β-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation [PDF]

, 2013
A number of beta-thalassemia (β-thal) patients in the course of the disease exhibit ectopic calcification affecting skin, eyes and the cardiovascular system.
Vermeer, Cees, QUAGLINO, Daniela, Paolinelli-deVincenzi, Chiara, ANNOVI, Giulia, Schurgers, L., BORALDI, Federica, Garcia-Fernandez, Maria, Ronchetti, Ivonne, PAOLINELLI DEVINCENZI, Chiara, Garcia Fernandez, M., Schurgers, Leon; id_orcid, Vermeer, C., Cianciulli, P., Ronchetti, I., Cianciulli, Paolo   +14 more
core   +1 more source