Results 101 to 110 of about 139,269 (266)

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Lysyl Oxidase in Ectopic Cardiovascular Calcification: Role of Oxidative Stress [PDF]

[eng] Lysyl oxidase (LOX)-mediated extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease; however, this enzyme also induces oxidative stress.
Vázquez-Sufuentes, P., Ballester-Servera, C., Alonso, J., Cañes, L., García-Redondo, A.B., Martínez-González, J., Rodríguez, C.   +6 more
core   +3 more sources

Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum [PDF]

, 2011
Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder in which calcification of connective tissue leads to pathology in skin, eye and blood vessels. PXE is caused by mutations in ABCC6.
Gorgels, TGMF (Theo), Ivandic, Boris, Ivandic, B. (Boris), Waarsing, J.H. (Jan), Schlingemann, Reinier O., Vermeer, C, Herfs, M, Versteeg, D, Bergen, Arthur, Schoensiegel, F, Sato, T, Cees Vermeer, Schlingemann, RO, Schoensiegel, Frank, Marjolein Herfs, Ivandic, B, Gorgels, T.G.M.F. (Theo), Schoensiegel, F. (Frank), Schlingemann, R.O. (Reinier), Schurgers, LJ, Versteeg, D. (Daniëlle), Arthur A. B. Bergen, Schurgers, Leon J.; id_orcid, Bergen, Arthur A B, Schurgers, L.J. (Leon), Gorgels, Theo G. M. F., Theo G. M. F. Gorgels, Jan H. Waarsing, Sato, T. (Toshiro), Bergen, A.A.B. (Arthur), Daniëlle Versteeg, Frank Schoensiegel, Boris Ivandic, Herfs, Marjolein, Waarsing, Jan H., Sato, Toshiro, Vermeer, Cees, Waarsing, Jan, Toshiro Sato, Herfs, M. (Marjolein), Vermeer, C. (Cees), Reinier O. Schlingemann, Leon J. Schurgers, Versteeg, Danielle   +43 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Cell Phenotype Transitions in Cardiovascular Calcification

Frontiers in Cardiovascular Medicine, 2018
Cardiovascular calcification was originally considered a passive, degenerative process, however with the advance of cellular and molecular biology techniques it is now appreciated that ectopic calcification is an active biological process.
Luis Hortells, Swastika Sur, Cynthia St. Hilaire   +2 more
doaj   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Early pharmacological blockade of the CXCL12-CXCR4 axis attenuates vertebral hypercalcification in a zebrafish model of pseudoxanthoma elasticum

Biochemistry and Biophysics Reports
Pseudoxanthoma elasticum (PXE), caused by pathogenic variants in ABCC6, is characterized by pathological ectopic calcification with poorly understood mechanisms and no effective therapies.
Jianjian Sun, Jichang Huang, Renjie Zhang, Shubin Zhang, Tao P. Zhong, Ping Zhu   +5 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source