Results 121 to 130 of about 18,317 (173)

ED50 and ED95 of rocuronium during alfaxalone anesthesia in dogs

Veterinary Anaesthesia and Analgesia, 2023
To determine the median effective dose (ED50) and effective dose required to depress the twitch value by 95% (ED95) of rocuronium during alfaxalone anesthesia in dogs.A randomized, prospective, crossover experimental study.A total of eight adult Beagle dogs (four female, four male), weighing 10.3-14.6 kg and aged 6-8 years.The dogs were anesthetized ...
Takaharu Itami
exaly   +3 more sources

A Nomographic Probit Solution for the Median Effective Dose (ED50)

Journal of Immunology, 1950
Summary A simple and rapid nomographic probit solution for the median effective dose (ED50) is proposed. ED50 and the slope of the dosage-response curve are directly read off from the same nomogram. Additional nomograms convert death rates into probits, and give estimates of the standard error of ED50, the standard error of the slope ...
W, KOCH, D, KAPLAN
exaly   +3 more sources

Discrete Delta Estimation of the Variance of the Logistic Scores Estimator of ED50

Biometrical Journal, 1999
Summary: A discrete delta method is applied to estimation of the standard error of the logistic scores estimator of ED50 in quantal bioassay. Results of a simulation study suggest that the standard error estimator is useful for assessing the precision of the ED50 estimate and for interval estimation of ED50.
Cobb, E. Benton, Church, J. D.
exaly   +3 more sources

Determination of ED50 of hydromorphone for postoperative analgesia following cesarean delivery

International Journal of Obstetric Anesthesia, 2016
Morphine is the most common opioid injected into the intrathecal space for postoperative analgesia following cesarean delivery, but ongoing medication shortages have resulted in limited availability. One proposed morphine alternative is hydromorphone. Studies investigating its use in post-cesarean analgesia are limited.
Grant Lynde
exaly   +3 more sources

A comparison of estimators of the ED50 in up-and-down experiments

Journal of Statistical Computation and Simulation, 1987
Many estimators for the ED50 have been suggested for use in Up-and-Down experiments. Here m.l.e.s. and other estimators are compared by computer simulation of experiments, and calculation of asymptotic properties. Brownlee's "delayed" estimator and Dixon and Mood's estimator have mean squared errors that are usually close to or below that for the other
exaly   +2 more sources

An EfficientR-Estimator for the ED50

Journal of the American Statistical Association, 1984
Abstract Analogues of R-estimators are defined for the problem of estimating the median of a symmetric tolerance distribution in quantal bioassay. Asymptotic distributions are derived, and it is shown that the logistic scores estimator is, in a certain sense, asymptotically efficient.
Barry R. James, Kang Ling James, Henrique Westenberger   +2 more
openaire   +1 more source

Median Effective Doses (ED50) of Halothane in Adults and Children

Anesthesiology, 1969
Median effective doses of halothane (ED50), determined in 73 pediatric subjects and 31 adults grouped according to age, were: 1.20 per cent at 0 to 6 months; 1.16 per cent at 6 to 24 months; 1.07 per cent at 24 to 48 months; and 0.9 per cent in adults. The dose-response curves for all groups did not deviate significantly from parallelism. Halothane was
H F, Nicodemus, C, Nassiri-Rahimi, L, Bachman, T C, Smith   +3 more
openaire   +2 more sources

Robust Estimates of the ED50

Journal of the American Statistical Association, 1979
Abstract To explore the possibility that robust estimators of location can be adapted to the problem of estimating the ED50 in binary-response bioassay, 10 estimators are compared. A Monte Carlo study is conducted to determine the mean squared errors (MSE) of the estimators. Taking into account the MSE for a variety of symmetric tolerance distributions,
openaire   +1 more source

Trimmed Logit Method for Estimating the ED50 in Quantal Bioassay

Biometrics, 1987
Trimmed nonparametric procedures such as the trimmed Spearman-Karber method have been proposed in the literature for overcoming the deficiencies of the probit and logit models in the analysis of quantal bioassay data. However, there are situations where the median effective dose (ED50) is not calculable with the trimmed Spearman-Karber method, but is ...
L P, Sanathanan, E T, Gade, N L, Shipkowitz   +2 more
openaire   +2 more sources

Estimation of ED50 or LD50 using a programmable pocket calculator

Computers in Biology and Medicine, 1991
A program is developed for estimation of median effective dose (ED50 or LD50), using the hand-held programmable pocket calculator HP41CV. The well-known Finney's algorithm of probit analysis is used. Input of data is simple, but is restricted to a maximum of 15 groups. The program structure makes use of the technique of indirect addressing for storage,
S C, Mehta, D K, Jain, C K, Gupta
openaire   +2 more sources