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Search-and-replace genome editing without double-strand breaks or donor DNA
Nature, 2019 Most genetic variants that contribute to disease1 are challenging to correct efficiently and without excess byproducts2–5. Here we describe prime editing, a versatile and precise genome editing method that directly writes new genetic information into a ...
Peyton B Randolph +2 more
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Locating and Editing Factual Associations in GPT
Neural Information Processing Systems, 2022We analyze the storage and recall of factual associations in autoregressive transformer language models, finding evidence that these associations correspond to localized, directly-editable computations.
Kevin Meng +3 more
semanticscholar +1 more source
MasaCtrl: Tuning-Free Mutual Self-Attention Control for Consistent Image Synthesis and Editing
IEEE International Conference on Computer Vision, 2023Despite the success in large-scale text-to-image generation and text-conditioned image editing, existing methods still struggle to produce consistent generation and editing results.
Ming Cao +5 more
semanticscholar +1 more source
Angewandte Chemie International Edition, 2023
AbstractStereochemical editing has recently risen to prominence, allowing the direct editing of organic molecules with stereocenter(s) to adjust their relative stereochemistry at a late‐stage. Several seminal light‐driven stereochemical editing reactions such as deracemization and epimerization have been successively developed.
Guangying Tan, Frank Glorius
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AbstractStereochemical editing has recently risen to prominence, allowing the direct editing of organic molecules with stereocenter(s) to adjust their relative stereochemistry at a late‐stage. Several seminal light‐driven stereochemical editing reactions such as deracemization and epimerization have been successively developed.
Guangying Tan, Frank Glorius
openaire +2 more sources
FateZero: Fusing Attentions for Zero-shot Text-based Video Editing
IEEE International Conference on Computer Vision, 2023The diffusion-based generative models have achieved remarkable success in text-based image generation. However, since it contains enormous randomness in generation progress, it is still challenging to apply such models for real-world visual content ...
Chenyang Qi +6 more
semanticscholar +1 more source
Nature Nanotechnology, 2020 CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that
Qiang Cheng, Tuo Wei, Lukas Farbiak
exaly +2 more sources
Annual Review of Neuroscience, 1996
RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum ...
L, Simpson, R B, Emeson
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RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum ...
L, Simpson, R B, Emeson
openaire +2 more sources