Results 51 to 60 of about 3,583,329 (296)

Target choice and exon skipping regulate CRISPR-directed gene editing of NRF2 in head/neck and esophageal cancer cells

Molecular Therapy: Oncology
Head and neck cancer (HNC) is the seventh most diagnosed cancer, with a predicted 30% increase annually by 2030. Conventional treatment is often combinatorial involving chemotherapy and radiation therapy, immunotherapy, and surgery, but over time ...
Natalia Rivera-Torres, Lauren E. Skelly, John A. Rogowskyj, Guadalupe Aguilar, Kelly Banas, Pawel Bialk, Eric B. Kmiec   +6 more
doaj   +1 more source

Zmogljivost sodobnih spletnih prevajalskih pripomočkov in njihova uporaba pri izobraževanju študentov prevajalstva

Jezik in Slovstvo, 2023
Nove tehnologije korenito posegajo in spreminjajo delo prevajalcev in tako pomembno vplivajo na prevajalski poklic in študij. Na te spremembe se morata odzvati tako praksa kot tudi prevajalski študijski programi.
Ada Gruntar Jermol, Mladen Rieger
doaj   +1 more source

Towards Certain Fixes with Editing Rules and Master Data [PDF]

, 2010
A variety of integrity constraints have been studied for data cleaning. While these constraints can detect the presence of errors, they fall short of guiding us to correct the errors. Indeed, data repairing based on these constraints may not
Fan, Wenfei, Li, Jianzhong, Ma, Shuai, Tang, Nan, Yu, Wenyuan   +4 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Double-strand break-free and transgene-free genome editing in the microalga Nannochloropsis oceanica using removable vectors containing the CRISPR base editing system

Scientific Reports
The accumulation of lipids by algae makes them attractive for carbon-neutral fuel production; however, the industrial-scale production of algal lipids has yet to be achieved.
Keishi Moroi, Takashi Yamamoto, Tomokazu Kurita   +2 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Automatic editing of manuals [PDF]

, 1970
The documentation problem is discussed that arises in getting all the many items included in a computer program prepared in a timely fashion and keeping them all correct and mutually consistent during the life of the program. The proposed approach to the
Rich, R. P.
core   +1 more source

Parameterizing edge modification problems above lower bounds

, 2016
We study the parameterized complexity of a variant of the $F$-free Editing problem: Given a graph $G$ and a natural number $k$, is it possible to modify at most $k$ edges in $G$ so that the resulting graph contains no induced subgraph isomorphic to $F ...
Froese, Vincent, Komusiewicz, Christian, van Bevern, René   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing

Genome Biology
Chromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang, Pengchong Fu, Ziheng Chen, Xiangnan Wang, Hanhui Ma, Xuedi Zhang, Guanjun Gao   +6 more
doaj   +1 more source