Results 101 to 110 of about 4,492,164 (288)

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

open access: yesAdvanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen   +15 more
wiley   +1 more source

Appropriation, réemploi et transfert. Du concours de l’image dans la traduction de Travels through the Interior Parts of America de Thomas Anburey

open access: yesViatica
This analysis of Thomas Anburey’s Travels through the Interior Parts of America is based on different editions and translations published between 1789 and 1793.
Marie-Lise Poirier   +2 more
doaj   +1 more source

«Un vero scrittore internazionale». La diffusione mondiale delle opere di Giorgio Bassani

open access: yesCahiers d’Études Italiennes, 2018
This paper reconstructs the international circulation of Bassani’s œuvre. The analysis of Bassani’s correspondence with publishers and translators shows his strong determination to convey his intellectual and moral message to a wide international ...
Rosy Cupo
doaj   +1 more source

Giving in Minnesota 2009 Edition Summary [PDF]

open access: yes, 2009
This summary reports highlights of the Minnesota Council on Foundations' Giving in Minnesota, 2009 Edition research report, the most comprehensive analysis of charitable giving in the state.
Anne Graham, Julian Tillema, Wedny Wehr
core  

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

open access: yesAdvanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang   +21 more
wiley   +1 more source

Drive-By America: Second Edition [PDF]

open access: yes, 2010
Drive-by shootings are commonly defined as an incident in which the shooterfires a firearm from a motor vehicle at another person, vehicle, building, or another stationary object.This study is a follow-up to the July 2007 Violence Policy Center (VPC ...

core  

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

A Profile of Today's Hunter - Social and Economic Highlights [PDF]

open access: yes, 2005
This edition condenses the findings of the latest studies examining hunters and hunting in America and the social, political and economic necessity of hunting in today's ...

core  

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

open access: yesAdvanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li   +25 more
wiley   +1 more source

Manuscrit de base et variantes de tradition dans le Chevalier de la charrette

open access: yesPerspectives Médiévales, 2012
In the last decades, thanks to the development of new technologies, scholars have been provided with a large amount of digital resources and data. For Chrétien de Troyes’ Conte de la charrette, such an improvement is mainly due to the homonymous Project ...
Stefano Asperti   +2 more
doaj   +1 more source

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