Results 71 to 80 of about 820,443 (350)

Reinventing discovery learning: a field-wide research program [PDF]

, 2017
© 2017, Springer Science+Business Media B.V., part of Springer Nature. Whereas some educational designers believe that students should learn new concepts through explorative problem solving within dedicated environments that constrain key parameters of ...
Abrahamson, D, Kapur, M
core   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

The Effect of Educational Games on Creativity: A systematic Review [PDF]

Iranian Journal of Educational Research
Objective: Games serve as an apt instrument for promoting innovative pedagogical approaches. The objective of the current investigation is to examine the influence of educational games on creativity through a methodical exploration.
Mohadeseh Ziaee, Mohsen Rostamy-MalKhalifeh, Tofigh Allahviranloo   +2 more
doaj  

Development of Educational Games Based on Design Thinking to Improve Mathematical Thinking Skills

Qalamuna
The development of technology has a significant impact on the world of education. One of them is the use of games as a learning medium. This study aims to develop an educational game integrated with a live worksheet.
Muhtarom Muhtarom, Sugiyanti Sugiyanti, Muhammad Saifuddin Zuhri, Nur Latifah Dwi Mutiara, Hendrisa Adrillian, Milagros Baldemor   +5 more
doaj   +1 more source

Educational games - are they worth the effort? A literature survey of the effectiveness of serious games [PDF]

, 2013
Over the last decade educational games have become more and more popular. There are many games specifically designed as educational games, as well as a number of entertainment games that have been successfully used for educational purposes.
Backlund, P., Hendrix, Maurice
core   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Digital educational games & phonological awareness [PDF]

, 2017
O presente artigo expõe os resultados de uma investigação centrada na validação de «Jogos Educativos Digitais», recorrendo ao programa PowerPoint da Microsoft, os quais visam o desenvolvimento da consciência fonológica, em crianças em idade pré-escolar ...
cervera, costa, francisco, freitas, gil, gil, rios, rosa, sim-sim, sim-sim, valente, vásquez   +11 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Physical Implementation of Optical Material‐Based Neural Networks Processing Enabled by Long‐Persistent Luminescence

Advanced Science, EarlyView.
This study reports on the physical implementation of optical material‐based neural processing using long‐persistent luminescence as memory‐retention and nonlinear optical material. The system performs optical‐domain preprocessing with opto‐electronic interfaces for stimulus delivery and readout, enabling real‐time demonstrations including Pong gameplay
Sangwon Wi, Yunsang Lee
wiley   +1 more source