Results 91 to 100 of about 5,339,479 (329)

The Expected Fitness Cost of a Mutation Fixation under the One-dimensional Fisher Model [PDF]

, 2009
This paper employs Fisher’s model of adaptation to understand the expected fitness effect of fixing a mutation in a natural population. Fisher’s model in one dimension admits a closed form solution for this expected fitness effect. A combination of different
Watson, Layne T., Zhang, Liqing
core   +1 more source

Neutral Evolution as Diffusion in phenotype space: reproduction with mutation but without selection

, 2007
The process of `Evolutionary Diffusion', i.e. reproduction with local mutation but without selection in a biological population, resembles standard Diffusion in many ways.
A. Winter, B. Derrida, B. Rannala, D. Kannan, Daniel John Lawson, G. Slade, Henrik Jeldtoft Jensen, M. Kimura, N. T. J. Bailey, P. A. P. Moran, S. Gavrilets, S. Hubbell, T. Ohta, W. Paul   +13 more
core   +2 more sources

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source

Comparing Genetic Ne Reconstructions Over Time With Long‐Time Wolf Monitoring Data in Two Populations

Evolutionary Applications
Many methods are now available to calculate Ne, but their performance varies depending on assumptions. Although simulated data are useful to discover certain types of bias, real empirical data supported by detailed known population histories allow us to ...
Laia Pérez‐Sorribes, Pau Villar‐Yanez, Linnéa Smeds, Joachim Mergeay   +3 more
doaj   +1 more source

Inference of historical population-size changes with allele-frequency data

, 2020
With up to millions of nearly neutral polymorphisms now being routinely sampled in population-genomic surveys, it is possible to estimate the site-frequency spectrum of such sites with high precision.
Haubold, B., Lynch, M., Maruki, T., Pfaffelhuber, P.   +3 more
core   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Effective Size of Fluctuating Salmon Populations

Genetics, 2002
AbstractPacific salmon are semelparous but have overlapping year classes, which presents special challenges for the application of standard population genetics theory to these species. This article examines the relationship between the effective number of breeders per year (Nb) and single-generation and multigeneration effective population size (Ne) in
openaire   +2 more sources

Testing demographic models of effective population size [PDF]

Proceedings of the Royal Society of London. Series B: Biological Sciences, 2001
Due to practical difficulties in obtaining direct genetic estimates of effective sizes, conservation biologists have to rely on so-called 'demographic models' which combine life-history and mating-system parameters with F-statistics in order to produce indirect estimates of effective sizes.
Basset, P., Balloux, F., Perrin, N.
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Detecting past changes of effective population size [PDF]

Evolutionary Applications, 2014
AbstractUnderstanding and predicting population abundance is a major challenge confronting scientists. Several genetic models have been developed using microsatellite markers to estimate the present and ancestral effective population sizes. However, to get an overview on the evolution of population requires that past fluctuation of population size be ...
Nikolic, Natacha, Chevalet, Claude
openaire   +6 more sources