Results 131 to 140 of about 5,339,479 (329)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Observational and Theoretical Tidal Radii of Globular Clusters in M87

, 2012
Globular clusters have linear sizes (tidal radii) which theory tells us are determined by their masses and by the gravitational potential of their host galaxy.
Alison Sills, Barmby, Bertin, Binney, Blakeslee, Casetti-Dinescu, Côté, Dinescu, Ferrarese, Gomez, Harris, Harris, Jeremy J. Webb, Jórdan, Madrid, McLaughlin, McLaughlin, Meylan, Peng, Prieto, Spitler, Sérsic, Waters, William E. Harris, Zait   +24 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

EVOLUTION OF RELIGIOUS CAPACITY IN THE GENUS HOMO: ORIGINS AND BUILDING BLOCKS

Zygon, 2018
The large, ancient ape population of the Miocene reached across Eurasia and down into Africa. From this genetically diverse group, the chimpanzees, bonobos, gorillas, and humans evolved from populations of successively reduced size.
doaj   +2 more sources

Effect of linkage on the control of inbreeding in selection programmes

Genetics Selection Evolution, 2000
Selection and mating methods for controlling inbreeding in selection programmes are based on relationships obtained from pedigrees. The efficiency of these methods has always been tested by studies using genetic models of independent loci. However, under
Caballero Armando, Toro Miguel A, Santiago Enrique, Fernández Blanca   +3 more
doaj   +1 more source

Inferring Past Effective Population Size from Distributions of Coalescent Times

Genetics, 2016
Inferring and understanding changes in effective population size over time is a major challenge for population genetics. Here we investigate some theoretical properties of random-mating populations with varying size over time.
Lucie M. Gattepaille, Torsten Günther, M. Jakobsson   +2 more
semanticscholar   +1 more source

GCIRS 7, a pulsating M1 supergiant at the Galactic centre. Physical properties and age

, 2014
The stellar population in the central parsec of the Galaxy is dominated by an old (several Gyr) population, but young, massive stars dominate the luminosity function.
Bouquin, J. B. Le, Brandner, W., Breitfelder, J., Burtscher, L., Gillessen, S., Haubois, X., Kervella, P., Martins, F., Ott, T., Paumard, T., Perrin, G., Pfuhl, O., Pott, J. -U.   +12 more
core   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Herbicide impacts on exotic grasses and a population of the critically endangered herb "Calystegia affinis" (Convolvulaceae) on Lord Howe Island [PDF]

, 2013
Introduced perennial grasses are capable of altering the habitat of native species, causing reductions in population size and vigour, and potentially affecting life-history processes such as survival, pollination and seedling recruitment. We examined the
Auld, Tony D., Brown, Dianne, Coenraads, Robert, Denham, Andrew J., Hutton, Ian, Ooi, M. K. J.   +5 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source