Results 151 to 160 of about 1,472,050 (256)

Spatio-Temporal Changes in Effective Population Size in an Expanding Metapopulation of Eurasian Otters. [PDF]

Evol Appl
Thomas NE, Chadwick EA, Bruford MW, Hailer F.   +3 more
europepmc   +1 more source

Identity-by-descent-based estimation of the X chromosome effective population size with application to sex-specific demographic history. [PDF]

G3 (Bethesda), 2023
Cai R, Browning BL, Browning SR.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of Social Structure on Effective Population Size Change Estimates. [PDF]

Evol Appl
Parreira BR, Gopalakrishnan S, Chikhi L.
europepmc   +1 more source

Drivers of strong isolation and small effective population size at a leading range edge of a widespread plant. [PDF]

Heredity (Edinb), 2023
Cisternas-Fuentes A, Koski MH.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Effective population size of <i>Culex quinquefasciatus</i> under insecticide-based vector management and following Hurricane Harvey in Harris County, Texas. [PDF]

Front Genet, 2023
Huang X, Athrey GN, Kaufman PE, Fredregill C, Slotman MA.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effective population size does not explain long-term variation in genome size and transposable element content in animals. [PDF]

Elife
Marino A, Debaecker G, Fiston-Lavier AS, Haudry A, Nabholz B.   +4 more
europepmc   +1 more source

Genetic diversity, structure, and effective population size of an endangered, endemic hoary bat, 'ōpe'ape'a, across the Hawaiian Islands. [PDF]

PeerJ, 2023
Pinzari CA, Bellinger MR, Price D, Bonaccorso FJ.   +3 more
europepmc   +1 more source