Results 141 to 150 of about 3,891,523 (334)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The genetic status and rescue measure for a geographically isolated population of Amur tigers

Scientific Reports
The Amur tiger is currently confronted with challenges of anthropogenic development, leading to its population becoming fragmented into two geographically isolated groups: smaller and larger ones.
Yao Ning, Dongqi Liu, Jiayin Gu, Yifei Zhang, Nathan James Roberts, Valentin Yu Guskov, Jiale Sun, Dan Liu, Ming Gong, Jinzhe Qi, Zhijian He, Chunmei Shi, Guangshun Jiang   +12 more
doaj   +1 more source

Historical effective population size of North American hoary bat (Lasiurus cinereus) and challenges to estimating trends in contemporary effective breeding population size from archived samples

, 2021
Robert S. Cornman, Jennifer A. Fike, Sara J. Oyler‐McCance, Paul M. Cryan   +3 more
openalex   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Estimating effective population size using close‐kin mark–recapture

Methods in Ecology and Evolution
Close‐kin mark–recapture (CKMR) is a method that allows estimating population census size, among other parameters, through the observed number of pairs that are close‐kin including parent–offspring pairs (POPs) and half‐sibling pairs (HSPs).
Jonathan Babyn, Daniel Ruzzante, Mark Bravington, Joanna Mills Flemming   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Population bottleneck and effective size in Bonamia ostreae-resistant populations of Ostrea edulis as inferred by microsatellite markers [PDF]

, 2001
Sophie Launey, Marc Barre, A. Gérard, Yamama Naciri   +3 more
openalex   +1 more source

A Note on the Inbreeding Effective Population Size [PDF]

Evolution, 1992
Armando, Caballero, William G, Hill
openaire   +2 more sources

Estimating the Effective Size of European Wolf Populations

Evolutionary Applications
ABSTRACTMolecular methods are routinely used to estimate the effective size of populations (Ne). However, underlying model assumptions are frequently violated to an unknown extent. Although simulations can detect sources of bias and help to adjust sampling strategies and analyses methods, additional information from empirical data can also be used to ...
Joachim Mergeay, Sander Smet, Sebastian Collet, Sabina Nowak, Ilka Reinhardt, Gesa Kluth, Maciej Szewczyk, Raquel Godinho, Carsten Nowak, Robert W. Mysłajek, Gregor Rolshausen   +10 more
openaire   +4 more sources