Results 131 to 140 of about 1,499,816 (300)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Ratios of effective population size and estimates of gene flow.
, 2013 Abbreviations: N1/N2, effective population size ratio between population 1 and population 2; m1-2, effective number of haplotypes migrating from population 1 to population 2 per year; m2-1, effective number of haplotypes migrating from population 2 to ...
Paolo Anagnostou (161204) +9 more
core +1 more source
Effect of linkage on the control of inbreeding in selection programmes
Genetics Selection Evolution, 2000 Selection and mating methods for controlling inbreeding in selection programmes are based on relationships obtained from pedigrees. The efficiency of these methods has always been tested by studies using genetic models of independent loci. However, under
Caballero Armando +3 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Estimates of effective population size inPinus silvestris
, 1972 The effective population size for inbreeding has been estimated in a 70 years old population of Scotch Pine in three consecutive years to be 0.46, 0.55 and 0.61 respectively of the actual total population. The following formula was developed to determine
Gregorius, H. R., Stern, K.
core +1 more source
Population Size and Effectiveness of Selection [PDF]
Evolution, 1954 Everett R. Dempster, I. Michael Lerner
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Introgression Makes Waves in Inferred Histories of Effective Population Size
, 2017 Human populations have a complex history of introgression and of changing population size. Human genetic variation has been affected by both these processes, so that inference of past population size depends upon the pattern of gene flow and ...
Hawks, John, John Hawks
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Estimation of the variance effective population size in age structured populations
, 2015 The variance effective population size for age structured populations is generally hard to estimate and the temporal method often gives biased estimates. Here, we give an explicit expression for a correction factor which, combined with estimates from the
Olsson, Fredrik, +3 more
core +1 more source