Results 181 to 190 of about 1,499,816 (300)

Haplotype-based inference of recent effective population size in modern and ancient DNA samples. [PDF]

Nat Commun, 2023
Fournier R, Tsangalidou Z, Reich D, Palamara PF.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Importance of Effective Population Size in Conservation and Biodiversity Monitoring. [PDF]

Evol Appl
Mergeay J, Gargiulo R, Moodley Y, Russo IR.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Estimating Linkage Disequilibrium and Effective Population Size Across Generations in Holstein Cattle. [PDF]

Vet Med Sci
Salehi R, Javanmard A, Mokhber M, Alijani S.   +3 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Genomic Evidence of Low Contemporary Effective Population Size and Southern Genetic Reservoirs in an Island Endemic Epiphytic Orchid of Taiwan. [PDF]

Ecol Evol
Chen WY, Sun Y, Wu SP, Huang JP.
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Effective Population Size and Genomic Inbreeding in Slovak Pinzgau Cattle

, 2017
The aim of this study was to evaluate the level of genomic inbreeding and effective population size in the Slovak Pinzgau population based on molecular – genetic analysis. The genotyping data was obtained from in total 152 animals (37 sires, and 115 cows)
Kadlečik, Ondrej, Veronika Kukučkovà, Kasarda, Radovan, Nina Moravčikovà, Kukučkovà, Veronika, Radovan Kasarda, Ondrej Kadlečik, Moravčikovà, Nina   +7 more
core  

Estimating the optimal number of samples to determine the effective population size in livestock. [PDF]

Front Genet
Manunza A, Cozzi P, Boettcher P, Curik I, Looft C, Colli L, Sölkner J, Mészáros G, Stella A.   +8 more
europepmc   +1 more source