Results 51 to 60 of about 3,891,523 (334)

Effective Population Size and Population Subdivision in Demographically Structured Populations [PDF]

Genetics, 2002
Abstract A fast-timescale approximation is applied to the coalescent process in a single population, which is demographically structured by sex and/or age. This provides a general expression for the probability that a pair of alleles sampled from the population coalesce in the previous time interval.
Valérie, Laporte, Brian, Charlesworth
openaire   +2 more sources

The effect of neighborhood size on effective population size in theory and in practice [PDF]

Heredity, 2016
The distinction between the effective size of a population (Ne) and the effective size of its neighborhoods (Nn) has sometimes become blurred. Ne reflects the effect of random sampling on the genetic composition of a population of size N, whereas Nn is a measure of within-population spatial genetic structure and depends strongly on the dispersal ...
openaire   +4 more sources

The effect of sample size on estimates of genetic differentiation and effective population size for Schistosoma mansoni populations [PDF]

International Journal for Parasitology, 2018
Eradication or local extinction of the human parasite Schistosoma mansoni is a goal for many control programs. Population genetic analyses are helping to evaluate and guide these efforts, yet what to sample, how to sample and how densely to sample is not well established. We determined the S.
Lúcio M. Barbosa, Bruna C. Barros, Moreno de Souza Rodrigues, Luciano K. Silva, Mitermayer G. Reis, Ronald E. Blanton   +5 more
openaire   +2 more sources

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Breeding Strategies to Optimize Effective Population Size in Low Census Captive Populations: The Case of Gazella cuvieri

Animals, 2021
Small-sized animal populations can undergo significant loss of genetic variability that can lead to their extinction. Therefore, studies on animal breeding have focused on mating systems for minimizing the disappearance of genetic variability.
Candela Ojeda-Marín, Isabel Cervantes, Eulalia Moreno, Félix Goyache, Juan Pablo Gutiérrez   +4 more
doaj   +1 more source

The effect of population structure, plant size, herbivory and reproductive potential on effective population size in the temperate epiphytic orchid, Sarcochilus australis [PDF]

, 2013
Distribution of plant size and reproductive success is investigated in the temperate epiphytic orchid Sarcochilus australis (Lindl.) Rchb. f. at Kinglake National Park, Victoria, in south-eastern Australia, and applied to estimating the effective ...
Tremblay, Raymond L.
core  

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation

BMC Genomics, 2020
Background In bacteria, pan-genomes are the result of an evolutionary “tug of war” between selection and horizontal gene transfer (HGT). High rates of HGT increase the genetic pool and the effective population size (N e ), resulting in open pan-genomes ...
Mirna Vázquez-Rosas-Landa, Gabriel Yaxal Ponce-Soto, Jonás A. Aguirre-Liguori, Shalabh Thakur, Enrique Scheinvar, Josué Barrera-Redondo, Enrique Ibarra-Laclette, David S. Guttman, Luis E. Eguiarte, Valeria Souza   +9 more
doaj   +1 more source

THE EFFECTS OF POPULATION BOTTLENECKS ON CLONAL INTERFERENCE, AND THE ADAPTATION EFFECTIVE POPULATION SIZE [PDF]

Evolution, 2009
Clonal interference refers to the competition that arises in asexual populations when multiple beneficial mutations segregate simultaneously. A large body of theoretical and experimental work now addresses this issue. Although much of the experimental work is performed in populations that grow exponentially between periodic population bottlenecks, the ...
Paolo R A, Campos, L M, Wahl
openaire   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source