Results 71 to 80 of about 5,339,479 (329)

Individualized Medicine in Africa: Bringing the Practice Into the Realms of Population Heterogeneity

Frontiers in Genetics, 2022
The declared aim of “personalized”, “stratified” or “precision” approaches is to place individual variation, as ascertained through genomic and various other biomarkers, at the heart of Scientific Medicine using it to predict risk of disease or response ...
Ayman A. Hussein, Reem Hamad, Melanie J. Newport, Muntaser E. Ibrahim   +3 more
doaj   +1 more source

Modeling the Growth and Decline of Pathogen Effective Population Size Provides Insight into Epidemic Dynamics and Drivers of Antimicrobial Resistance

bioRxiv, 2017
Non-parametric population genetic modeling provides a simple and flexible approach for studying demographic history and epidemic dynamics using pathogen sequence data. Existing Bayesian approaches are premised on stationary stochastic processes which may
E. Volz, X. Didelot
semanticscholar   +1 more source

Extensions of the Coalescent Effective Population Size [PDF]

Genetics, 2009
Abstract We suggest two extensions of the coalescent effective population size of Sjödin  et al. (2005) and make a third, practical point. First, to bolster its relevance to data and allow comparisons between models, the coalescent effective size should be recast as a kind of mutation effective size.
John, Wakeley, Ori, Sargsyan
openaire   +2 more sources

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques. [PDF]

, 2015
BACKGROUND:How a potentially diverse population of hematopoietic stem cells (HSCs) differentiates and proliferates to supply more than 10(11) mature blood cells every day in humans remains a key biological question.
Chen, Irvin SY, Chou, Tom, Goyal, Sidhartha, Kim, Sanggu   +3 more
core   +1 more source

Molecular Methods for Rare Hemoglobinopathy Cases: First Brazilian Report of Pediatric Siblings with Hb O‐Arab and Alpha‐Thalassemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk, Amanda Cristina Meneguetti Berti, Bárbara Braga Vieira Marques, Victoria Simões Bernardo, Flaviene Felix Torres, Ingrid Souza Dias, Vanessa da Silveira Ramos de Castro, Gabriela Alves Bernardino, Danilo Grünig Humberto da Silva, Edis Belini‐Júnior   +9 more
wiley   +1 more source

Extended and Continuous Decline in Effective Population Size Results in Low Genomic Diversity in the World’s Rarest Hyena Species, the Brown Hyena

Molecular biology and evolution, 2018
Hyenas (family Hyaenidae), as the sister group to cats (family Felidae), represent a deeply diverging branch within the cat‐like carnivores (Feliformia). With an estimated population size of
M. Westbury, S. Hartmann, A. Barlow, I. Wiesel, Viyanna Leo, Rebecca J. Welch, D. Parker, Florian Sicks, A. Ludwig, L. Dalén, M. Hofreiter   +10 more
semanticscholar   +1 more source

Criterion‐Related Validity of the Neuropsychological Quick Assessment for Screening Cognitive, Motor, and Behavioral Impairments in Patients With Pediatric Brain Tumors: An Observational Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neuropsychological complications may impair the qualitative prognosis of patients with pediatric brain tumors. However, multifaceted evaluations cannot be conducted in all patients because they are time consuming and burdensome for patients.
Ami Tabata, Keita Ueda, Tsukasa Ueno, Katsutsugu Umeda, Kentaro Ueno, Kanade Tanaka, Noyuri Nishida, Rie Yamawaki, Megumi Nukui, Yoshiki Arakawa   +9 more
wiley   +1 more source

Effective population sizes in cattle, sheep, horses, pigs and goats estimated from census and herdbook data

Animal, 2016
Accurate measures of effective population sizes (Ne) in livestock require good quality data and specialized skills for their computation and analysis. Ne can be estimated by Wright’s equation Ne=4MF/(M+ F) (M, F being sires and dams, respectively), but ...
S.J.G. Hall
doaj   +1 more source

Accurate Estimation of Effective Population Size in the Korean Dairy Cattle Based on Linkage Disequilibrium Corrected by Genomic Relationship Matrix [PDF]

Asian-Australasian Journal of Animal Sciences, 2013
Linkage disequilibrium between markers or genetic variants underlying interesting traits affects many genomic methodologies. In many genomic methodologies, the effective population size (Ne) is important to assess the genetic diversity of animal ...
Dong-Hyun Shin, Kwang-Hyun Cho, Kyoung-Do Park, Hyun-Jeong Lee, Heebal Kim   +4 more
doaj   +1 more source

Large deviations associated with Poisson--Dirichlet distribution and Ewens sampling formula

, 2007
Several results of large deviations are obtained for distributions that are associated with the Poisson--Dirichlet distribution and the Ewens sampling formula when the parameter $\theta$ approaches infinity.
Feng, Shui
core   +1 more source