Results 41 to 50 of about 219,266 (297)

CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors [PDF]

, 1988
The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments.
Jonjic, Stipan, Koszinowski, Ulrich H., Mutter, Wolfgang, Reddehase, Matthias J., Weiland, Frank   +4 more
core   +1 more source

Effector T Cell Differentiation and Memory T Cell Maintenance Outside Secondary Lymphoid Organs [PDF]

The Journal of Immunology, 2006
Abstract Naive T cell circulation is restricted to secondary lymphoid organs. Effector and memory T cells, in contrast, acquire the ability to migrate to nonlymphoid tissues. In this study we examined whether nonlymphoid tissues contribute to the differentiation of effector T cells to memory cells and the long-term maintenance of memory ...
Jagdeep S, Obhrai, Martin H, Oberbarnscheidt, Timothy W, Hand, Lonnette, Diggs, Geetha, Chalasani, Fadi G, Lakkis   +5 more
openaire   +2 more sources

Vaccine adjuvant-elicited CD8+ T cell immunity is co-dependent on T-bet and FOXO1

Cell Reports, 2023
Summary: T-bet and FOXO1 are transcription factors canonically associated with effector and memory T cell fates, respectively. During an infectious response, these factors direct the development of CD8+ T cell fates, where T-bet deficiency leads to ...
Daria L. Ivanova, Scott B. Thompson, Jared Klarquist, Michael G. Harbell, Augustus M. Kilgore, Erika L. Lasda, Jay R. Hesselberth, Christopher A. Hunter, Ross M. Kedl   +8 more
doaj   +1 more source

The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]

, 2018
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I., Macleod, Megan K.L., Westerhof, Lotus   +2 more
core   +1 more source

AILIM/ICOS signaling induces T-cell migration/polarization of memory/effector T-cells [PDF]

International Immunology, 2004
AILIM/ICOS has critical roles in the regulation of T-cell differentiation and effector T-cell function in various immune responses. The counter-ligand for AILIM/ICOS, B7h, is widely expressed in not only lymphoid tissue and antigen-presenting cells, but also in fibroblast and endothelial cells in various organs.
Naokazu, Okamoto, Yuko, Nukada, Katsunari, Tezuka, Kazumasa, Ohashi, Kensaku, Mizuno, Takashi, Tsuji   +5 more
openaire   +2 more sources

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

Journal of Translational Medicine, 2007
Background Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease.
Novitskaya Inna, Khatcherian Artemis, Cardinale Irma, Sullivan-Whalen Mary, Gilleaudeau Patricia, Kikuchi Toyoko, Lee Edmund, Lin Shao-Lee, Chamian Francesca, Wittkowski Knut M, Krueger James G, Lowes Michelle A   +11 more
doaj   +1 more source

Recombinant BCG expressing the LTAK63 adjuvant increased memory T cells and induced long-lasting protection against Mycobacterium tuberculosis challenge in mice

Frontiers in Immunology, 2023
Vaccine-induced protection against Mycobacterium tuberculosis (Mtb) is usually ascribed to the induction of Th1, Th17, and CD8+ T cells. However, protective immune responses should also involve other immune cell subsets, such as memory T cells.
Lázaro Moreira Marques-Neto, Monalisa Martins Trentini, Alex Issamu Kanno, Dunia Rodriguez, Luciana Cezar de Cerqueira Leite   +4 more
doaj   +1 more source

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels [PDF]

, 2017
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to ...
Asquith, Asquith, Asquith, Beura, Bingaman, Bjorkdahl, Bonhoeffer, Borghans, Bruno, Chao, Choo, De Boer, De Boer, De Boer, De Boer, Debacq, Ganusov, Ganusov, Grossman, Hogan, Hogan, Hogan, Hogan, Homann, Kassiotis, Le Campion, Leignadier, Lenz, Macallan, Min, Mohri, Mohri, Nelson, Parretta, Pepper, Pitcher, Purton, Restifo, Ribeiro, Robertson, Seddon, Surh, Tough, Vezys, Vrisekoop, Westera, Yates, Younes   +47 more
core   +4 more sources

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments

Cell Reports, 2018
Summary: T cells compete with malignant cells for limited nutrients within the solid tumor microenvironment. We found that effector memory CD4 T cells respond distinctly from other T cell subsets to limiting glucose and can maintain high levels of ...
Christopher Ecker, Lili Guo, Stefana Voicu, Luis Gil-de-Gómez, Andrew Medvec, Luis Cortina, Jackie Pajda, Melanie Andolina, Maria Torres-Castillo, Jennifer L. Donato, Sarya Mansour, Evan R. Zynda, Pei-Yi Lin, Angel Varela-Rohena, Ian A. Blair, James L. Riley   +15 more
doaj   +1 more source

Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation

Frontiers in Immunology, 2020
Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases.
Akane S. Suzuki, Ryoji Yagi, Motoko Y. Kimura, Chiaki Iwamura, Kenta Shinoda, Atsushi Onodera, Atsushi Onodera, Kiyoshi Hirahara, Damon J. Tumes, Damon J. Tumes, Ryo Koyama-Nasu, Siiri E. Iismaa, Robert M. Graham, Shinichiro Motohashi, Toshinori Nakayama   +14 more
doaj   +1 more source