Results 71 to 80 of about 219,266 (297)

A transcriptome-based model of central memory CD4 T cell death in HIV infection [PDF]

, 2016
BACKGROUND: Human central memory CD4 T cells are characterized by their capacity of proliferation and differentiation into effector memory CD4 T cells. Homeostasis of central memory CD4 T cells is considered a key factor sustaining the asymptomatic stage
Claudia Rangel-Escareño, Enrique Espinosa, Fany Gutiérrez-Jasso, Gustavo Olvera-García, Irma Aguilar-Delfín, Iván Imaz-Rosshandler, Joaquín Zúñiga, Joel A. Vázquez-Pérez, Lorena Orozco, Santiago Pérez-Patrigeon, Tania Aguilar-García   +10 more
core   +1 more source

Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells [PDF]

The Journal of Experimental Medicine, 2001
It has been proposed that two different antigen-experienced T cell subsets may be distinguishable by their preferential ability to home to lymphoid organs (central memory cells) or nonlymphoid tissues (effector memory/effector cells). We have shown recently that murine antigen-primed CD8+ T cells cultured in interleukin (IL)-15 (CD8IL-15) resemble ...
W, Weninger, M A, Crowley, N, Manjunath, U H, von Andrian   +3 more
openaire   +2 more sources

Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells

JCI Insight, 2023
Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were shown to be highly differentiated memory T cells with mixed signatures of dysfunction, activation, and effector function.
Shweta Mahajan, Aria Alexander, Zachary Koenig, Nicholas Saba, Nina Prasanphanich, David A. Hildeman, Claire A. Chougnet, Emily DeFranco, Sandra Andorf, Tamara Tilburgs   +9 more
openaire   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

T cells in vascular inflammatory diseases

Frontiers in Immunology, 2014
Inflammation of the human vasculature is a manifestation of many different diseases ranging from systemic autoimmune diseases to chronic inflammatory diseases, in which multiple types of immune cells are involved. For both autoimmune diseases and chronic
Lucas L Lintermans, Coen A Stegeman, Peter eHeeringa, Wayel H Abdulahad   +3 more
doaj   +1 more source

Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome [PDF]

, 2016
Objective The aim of this study was to evaluate over time circulating γδ T lymphocytes in melanoma patients in terms of frequency, effector functions, and relationship with clinical stage and evolution, by comparing preoperative values to those ...
Anfosso, A, Buccheri, S, Cordova, A, Dieli, F, Meraviglia, S, Moschella, F, Toia, F   +6 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Developmental epigenetic programming by Tet1/3 determines peripheral CD8 T cell fate

EMBO Reports
In response to infections, naive CD8 T cells give rise to effector and memory T cells. However, eliciting long-lived memory CD8 T cells remains a challenge for many infections.
Kara M Misel-Wuchter, Andrew L Thurman, Jordan T Johnson, Athmane Teghanemt, Neelam Gautam, Alejandro A Pezzulo, Jennifer R Bermick, Noah S Butler, Priya D Issuree   +8 more
doaj   +1 more source

Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure

Frontiers in Immunology, 2019
Recent studies demonstrate that the stable HIV-1 reservoir in resting CD4+ T cells is mostly formed from viruses circulating when combination antiretroviral therapy (ART) is initiated.
Nilu Goonetilleke, Nilu Goonetilleke, Genevieve Clutton, Genevieve Clutton, Ron Swanstrom, Ron Swanstrom, Sarah B. Joseph, Sarah B. Joseph, Sarah B. Joseph   +8 more
doaj   +1 more source