Results 101 to 110 of about 16,803 (230)

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Efferocytosis: the resolution of inflammation in cardiovascular and cerebrovascular disease

Frontiers in Immunology
Cardiovascular and cerebrovascular diseases have surpassed cancer as significant global health challenges, which mainly include atherosclerosis, myocardial infarction, hemorrhagic stroke and ischemia stroke.
Bingtao Zhang, Yan Zou, Zixuan Yuan, Kun Jiang, Zhaoxiang Zhang, Shujuan Chen, Xiaoming Zhou, Qi Wu, Xin Zhang   +8 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Identification of Seven in absentia homolog 2 as a potential efferocytosis-related biomarker in diabetic foot ulcers.

PLoS ONE
IntroductionWound of diabetic foot ulcers (DFU) is chronic and hard to heal, characterized by impaired inflammatory response, dysfunction of keratinocyte and endothelial cells and improper removal of dying cells. Efferocytosis, as a trigger for phenotype
Jiangli Zhao, Xuchen Liu, Qingyuan Sun, Yanya He, Jiwei Wang, Junzhi Liu, Chao Li, Fei Yan, Haoyong Jin, Zhiwei Xue, Ziyi Tang, Nan Su, Ning Yang, Xinyu Wang   +13 more
doaj   +1 more source

Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance [PDF]

, 2017
K
Garabuczi, Éva, Kiss, Beáta, Köröskényi, Krisztina, Sarang, Zsolt, Szondy, Zsuzsanna   +4 more
core   +1 more source

Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis

Cell Communication and Signaling
Background Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, a process by which macrophages clear apoptotic cells, plays a key role
Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar   +9 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration

Bioactive Materials
s: This comprehensive review elucidates the critical role of efferocytosis in tissue repair and regeneration processes, while systematically exploring innovative approaches through which tissue engineering strategies can modulate efferocytosis to ...
Yue-Qi Zhang, Rong Nie, Zi-Yuan Feng, Ming-Hui Fan, Zhi-Xue Shen, Xiu-Zhen Zhang, Qing-Yi Zhang, Chen-Yu Zou, Ji-Ye Zhang, Kai Huang, Li-Ping Mou, Hui-Qi Xie   +11 more
doaj   +1 more source

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis [PDF]

, 2017
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and ...
Ali, Sahl, Ballabio, Andrea, Bhattacharya, Somashubhra, Crowley, Jan R, Dehestani, Babak, Diwan, Abhinav, Epelman, Slava, Evans, Trent D, Fan, Daping, Holloway, Karyn B, Javaheri, Ali, Micevych, Paul S, Razani, Babak, Schilling, Joel D, Sergin, Ismail, Song, Eric, Stokes, Carl J, Weihl, Conrad C, Zayed, Mohamed A, Zhang, Xiangyu   +19 more
core   +2 more sources