Results 41 to 50 of about 16,803 (230)
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]
, 2016 Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping +7 more
core +2 more sources
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]
, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana +5 more
core +2 more sources
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer [PDF]
, 2016 Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves important roles in physiology by sculpting complex tissues during embryogenesis and by removing effete cells that have reached advanced age or whose genomes ...
Barcinski, M +15 more
core +1 more source
MafB is a critical regulator of complement component C1q [PDF]
, 2017 The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages.
Andrea Christina-Sylvia +24 more
core +1 more source
The complex TIE between macrophages and angiogenesis [PDF]
, 2020 Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration.
Anghelina M. +81 more
core +2 more sources
Vagus nerve controls resolution and pro-resolving mediators of inflammation [PDF]
, 2015 Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal ...
Dalli, Jesmond +4 more
core +1 more source
Extracellular Histones Inhibit Efferocytosis
Molecular Medicine, 2012 The uptake and clearance of apoptotic cells by macrophages and other phagocytic cells, a process called efferocytosis, is a major component in the resolution of inflammation. Increased concentrations of extracellular histones are found during acute inflammatory states and appear to contribute to organ system dysfunction and mortality. In these studies,
Arnaud, Friggeri +8 more
openaire +2 more sources
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation
EMBO Molecular Medicine, 2023 Efficient clearance of dying cells (efferocytosis) is an evolutionarily conserved process for tissue homeostasis. Genetic enhancement of efferocytosis exhibits therapeutic potential for inflammation resolution and tissue repair.
Ming‐Yue Wu +18 more
doaj +1 more source
Efferocytosis in Retinoblastoma
Journal of Cancer Therapy, 2013 Retinoblastoma has varied presentations. As age advances in retinoblastoma, the undifferentiated tumour is the common appearance. Apoptosis in retinoblastoma in an untreated case can give us a clue about the tumour biology. Efferocytosis in intraocular tumour is a new concept which was seen in an enucleated eyeball specimen in a 4-year-old boy ...
Dipankar Das +9 more
openaire +2 more sources
Efferocytosis Is an Innate Antibacterial Mechanism [PDF]
Cell Host & Microbe, 2012 Mycobacterium tuberculosis persists within macrophages in an arrested phagosome and depends upon necrosis to elude immunity and disseminate. Although apoptosis of M. tuberculosis-infected macrophages is associated with reduced bacterial growth, the bacteria are relatively resistant to other forms of death, leaving the mechanism underlying this ...
Martin, Constance J. +8 more
openaire +3 more sources