Results 51 to 60 of about 16,803 (230)

Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia. [PDF]

PLoS ONE, 2017
Efferocytosis by alveolar phagocytes (APs) is pivotal in maintenance of lung homeostasis. Increased efferocytosis by APs results in protection against lethal acute lung injury due to pulmonary infections whereas defective efferocytosis by APs results in ...
Sanjay Mukherjee, Renuka Subramaniam, Han Chen, Anthony Smith, Shiva Keshava, Homayoun Shams   +5 more
doaj   +1 more source

Phosphatidylserine-liposomes Promote Tolerogenic Features on Dendritic cells in human Type 1 Diabetes by apoptotic Mimicry [PDF]

, 2018
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find a safe approach to permanently cease autoimmunity and allow β-cell recovery has become ...
Aguilera, Eva, Briansó Castilla, Ferran, Cano Sarabia, Antonia María, García Jimeno, Sonia, Maspoch, Daniel, Perna Barrull, David, Pujol Autonell, Irma, Rodríguez Fernández, Silvia, Sánchez (Sànchez Pla), Álex, Verdaguer Autonell, Joan, Villalba, Adrian, Vives Pi, Marta, Vázquez San Miguel, Federico   +12 more
core   +3 more sources

Resolution of inflammation: a new therapeutic frontier [PDF]

, 2016
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success.
A Ariel, A Ariel, A Basran, A Boasso, A Chatterjee, A Devitt, A Kovalenko, A Recchiuti, A Recchiuti, A Rossi, AB Shyu, AE Leitch, AE Leitch, AG Rossi, AG Rossi, AG Rossi, AG Rossi, AI Medeiros, AJ Degraaf, AJ O'Brien, AL Alessandri, AL Alessandri, AL Robertson, AP Cope, AW Segal, B Amulic, B Bondue, B Geering, B Gemici, B Leon, BA Zabel, BJ Evans, C Favas, C Godson, C Qin, C Schauer, C von Roretz, C Yao, CA Wijbrandts, CC Mihalache, CD Buckley, CD Buckley, CD Gregory, CE Clay, CH Fong, CN Serhan, CN Serhan, CN Serhan, CW Yang, D Bhaumik, D El Kebir, D Park, DA Isenberg, DA Sawatzky, DC Cara, Derek W. Gilroy, DH Rodrigues, DR Gude, DS Straus, DW Gilroy, DW Gilroy, DW Gilroy, E Carballo, E Carballo, E Perdiguero, E Tili, EB Wilson, EE McGrath, EL Hahn, ES Mocarski, EY Chung, F Mariani, FJ Sheedy, FK Chan, FK Swirski, FM Menzies, FN Gavins, FS Machado, G D'Agostino, G Fredman, G Song, G Stoecklin, GA Rabinovich, GJ Bellingan, GJ Graham, GJ Graham, GL Bannenberg, H Braley-Mullen, H Muhl, H Nakano, H Seki, HJ Anders, HT Chung, I Allaeys, I McConnell, I Mitroulis, I Mitroulis, I Sauer, IK Poon, J Bystrom, J Bystrom, J Bystrom, J Gong, J Hopkins, J Liang, J Liu, J Liu, J Newson, J Savill, J Savill, J Seok, James N. Fullerton, JD Langereis, JD Pollock, JL Cash, JL Wallace, JM Gonzalez-Navajas, JM Schwab, JP Vago, JR Brown, JR Teijaro, JW Zmijewski, K Ersland, K Horino, K Lauber, K Linker, K Matsushita, K Miles, K Phillips, K Sasaki, K Takao, K Uchida, K Vyas, KD Taganov, KE Blume, KH Weylandt, KP High, L Arnold, L Chen, L Li, L Sun, LJ Harvey, LM Wakim, LP Sousa, LP Sousa, LR Prince, LS van Rijt, M Back, M Brittan, M Drechsler, M Feoktistova, M Kool, M Lagarde, M Mavers, M Perretti, M Perretti, M Piecyk, M Romano, M Romano, M Rosas, M Singh, M Vukmanovic-Stejic, MA Nahid, MC Martin, MF Schmidt, MG Johnston, MM Chan, MM Matzelle, MM Perry, MR Elliott, MR Jones, MR Junttila, MS Bynoe, MS Chapman, MT Elola, N Chiang, N Chiang, N Dufton, NC Henderson, NM Reddy, P Anderson, P Anderson, P Libby, P Ramachandran, P Sampath, PA Insel, Q Remijsen, R Gyurko, R Mounier, R Mukhopadhyay, R Pettipher, R Rajakariar, R Rajakariar, R Tomasini, RJ Nibbs, RL Ogilvie, RL Ogilvie, RM Day, RM Dores, RM Thurlings, RN Cahill, S Bala, S Brown, S Divanovic, S Krishnamoorthy, S Mi, S Parathath, S Schif-Zuck, S Uderhardt, S Yazid, S Yona, SB Berger, SG Trivedi, SJ Gardai, SJ Nicholls, SW Jones, SW Ryter, T Brzoska, T Hisada, T Lawrence, T Montero-Melendez, T Shay, T Vanden Berghe, U Koedel, UE Knies, V Deretic, VA Fadok, VA Fadok, VA Fadok, VA Fadok, VA Fadok, W Jenner, WH Shao, WJ Kim, WR Hansen, Y Fang, Y Fang, Y Okabe, Y Uehara, YL Chen   +239 more
core   +1 more source

MFG-E8 and HMGB1 Are Involved in the Mechanism Underlying Alcohol-Induced Impairment of Macrophage Efferocytosis

Molecular Medicine, 2013
Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1).
Xiao Wang, Heng-Fu Bu, Wei Zhong, Akihiro Asai, Zhanxiang Zhou, Xiao-Di Tan   +5 more
doaj   +1 more source

Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection. [PDF]

, 2016
HIV-1 disease progression is paradoxically characterized by systemic chronic immune activation and gut mucosal immune dysfunction, which is not fully defined.
Dandekar, Satya, Glavan, Tiffany, Goulart, Luiz R, Grishina, Irina, Jiang, Guochun, Sankaran-Walters, Sumathi, Sena, Angela AS   +6 more
core   +1 more source

Efferocytosis: another function of uPAR

Blood, 2009
uPAR, the receptor for urokinase plasminogen activator, is a regulator of the uptake by macrophages of apoptotic neutrophils (efferocytosis). Its role and mechanism appear to be complex and possibly controversial.
Blasi, Francesco, Sidenius, Nicolai
openaire   +3 more sources

Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?

Molecular Therapy: Oncolytics, 2020
Billions of cells undergo turnover and die via apoptosis throughout our lifetime. A prompt clearance of these apoptotic cells and debris by phagocytic cells, a process known as efferocytosis, is important in maintaining tissue homeostasis.
Danfeng Lin, Xiaodiao Kang, Lu Shen, Sheng Tu, Cameron Lenahan, Yiding Chen, Xiaochen Wang, Anwen Shao   +7 more
doaj   +1 more source

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]

, 2014
Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Targeting Efferocytosis in Inflammaging

Annual Review of Pharmacology and Toxicology
Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair. However, impaired efferocytosis can result in the accumulation of apoptotic cells, subsequently triggering sterile inflammation through the release of endogenous factors ...
Poon, Ivan K H, Ravichandran, Kodi S
openaire   +3 more sources