Results 11 to 20 of about 426,896 (336)
Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir
Pharmaceuticals, 2014 Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes.
Mitesh Patel +4 more
doaj +1 more source
Role of Efflux Pump Gene adeIJK to Multidrug Resistance in Acinetobacter baumanniiClinical Isolates
Annals of Clinical Microbiology, 2020 The emergence of multidrug-resistant Acinetobacter baumanniias a nosocomial pathogen is one of the major public health problems. The aim of this study was to evaluate the role of an efflux pump gene adeJ for the multidrug resistance of A ...
Ji Ae Choi +7 more
doaj +1 more source
Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions [PDF]
, 2016 The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents.
core +2 more sources
Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa
Frontiers in Microbiology, 2015 Pseudomonas aeruginosa infections are becoming increasingly difficult to treat due to intrinsic antibiotic resistance and the propensity of this pathogen to accumulate diverse resistance mechanisms.
Juerg eDreier, Paolo eRuggerone
doaj +1 more source
Antibiotics, 2019 We previously showed that berberine attenuates MexXY efflux-dependent aminoglycoside resistance in Pseudomonas aeruginosa. Here, we aimed to synthesize berberine derivatives with higher MexXY inhibitory activities. We synthesized 11 berberine derivatives,
Kenta Kotani +7 more
doaj +1 more source
The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells [PDF]
, 2019 Efflux pumps represent an important and large group of transporter proteins found in all organisms. The importance of efflux pumps resides in their ability to extrude a wide range of antibiotics, resulting in the emergence of multidrug resistance in many
Barras, Frederic +7 more
core +3 more sources
Importance of macrophage cholesterol content on the flux of cholesterol mass
Journal of Lipid Research, 2010 Net flux of cholesterol represents the difference between efflux and influx and can result in net cell-cholesterol accumulation, net cell-cholesterol depletion, or no change in cellular cholesterol content.
Sandhya Sankaranarayanan +5 more
doaj +1 more source
Frontiers in Microbiology, 2018 Fungal infections caused by Candida albicans and non-albicans Candida [NAC] species are becoming a growing threat in immunodeficient population, people with long-term antibiotic treatment and patients enduring kinds of catheter intervention.
Tianming Wang +6 more
doaj +1 more source
Unraveling the Underlying Heavy Metal Detoxification Mechanisms of Bacillus Species
Microorganisms, 2021 The rise of anthropogenic activities has resulted in the increasing release of various contaminants into the environment, jeopardizing fragile ecosystems in the process.
Badriyah Shadid Alotaibi +2 more
doaj +1 more source
Journal of Fungi, 2022 Recently, Candida glabrata has been recognized as one of the most common fungal species that is highly associated with invasive candidiasis. Its spread could be attributed to its increasing resistance to antifungal drugs.
Moneerah J. Alqahtani +4 more
doaj +1 more source