A Pseudomonas putida efflux pump acts on short-chain alcohols [PDF]
Biotechnology for Biofuels, 2018 Background The microbial production of biofuels is complicated by a tradeoff between yield and toxicity of many fuels. Efflux pumps enable bacteria to tolerate toxic substances by their removal from the cells while bypassing the periplasm.
Georg Basler +3 more
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A novel role for colistin as an efflux pump inhibitor in multidrug-resistant Klebsiella pneumoniae [PDF]
Scientific ReportsAntimicrobial resistance (AMR) is a global challenge that demands new strategies to maintain the effectiveness of current treatments. AMR arises through various mechanisms, including overexpression of drug efflux pumps. The AcrAB-TolC efflux pump is used
Rajnikant Sharma +7 more
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Exploring novel amides as efflux pump inhibitors for overcoming antibiotic resistance in multidrug-resistant Pseudomonas aeruginosa [PDF]
Iranian Journal of MicrobiologyBackground and Objectives: Pseudomonas aeruginosa (P. aeruginosa), a multidrug-resistant bacterium, represents a considerable risk in healthcare environments owing to its capacity to induce various infections. The resistance of P.
Fahad Ullah +9 more
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Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo [PDF]
Nature CommunicationsAntibiotic resistance is a threat to human health, yet recent work highlights how loss of resistance may drive pathogenesis in some bacteria. In two recent studies, we found that β-lactam antibiotics and nutrient stresses faced during infection selected ...
Sheryl E. Fernandes +12 more
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Evaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria [PDF]
Scientific ReportsAntimicrobial resistance concerning burdens is increasing day by day. Efflux pump upregulation is one of the mechanisms through which bacteria develop resistance to antibiotics.
Md. Momin-Reza +7 more
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Overexpression of the major facilitator superfamily efflux pump gene nfa56470 mediates ciprofloxacin resistance in Nocardia farcinica [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectivesTo explore the molecular basis of ciprofloxacin resistance in N. farcinica, providing a scientific basis for clinical antibiotic use and controlling the spread of resistant strains.MethodsWe analyzed 20 N. farcinica strains.
Chenchen Si +5 more
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Journal of Pure and Applied Microbiology, 2022 AcrAB-TolC is a resistance nodulation division type of efflux pump present in Enterobacteriaceae. It non-specifically effluxes antibiotics out of the bacterial cell, thus conferring drug resistance.
Priyadharshini Sekar +3 more
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Antibiotics, 2021 Acinetobacter species are among the most life-threatening Gram-negative bacilli, causing hospital-acquired infections, and they are associated with high morbidity and mortality. They show multidrug resistance that acts via various mechanisms.
Nagaraju Bankan +4 more
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The RND Efflux Pump Gene Expression in the Biofilm Formation of Acinetobacter baumannii
Antibiotics, 2023 Multidrug resistant (MDR) Acinetobacter baumannii is a critical opportunistic pathogen in healthcare-associated infections (HAI). This is attributed to several factors, including its ability to develop biofilms that can enhance antimicrobial resistance ...
Ola A. Abd El-Rahman +4 more
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Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. [PDF]
, 2020 The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Górecki, Kamil, McEvoy, Megan M
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