Results 141 to 150 of about 71,112 (299)

Flavonoids Identified in Terminalia spp. Inhibit Gastrointestinal Pathogens and Potentiate Conventional Antibiotics via Efflux Pump Inhibition

The genus Terminalia has a long history of use in traditional medicine to treat various diseases, including bacterial infections. We previously reported a metabolomic analysis using liquid chromatography–mass spectrometry of selected Australian ...
Muhammad Jawad Zai, Cheesman, Matthew James, Cock, Ian Edwin, Zai, Muhammad Jawad, Ian Edwin Cock, Matthew James Cheesman   +5 more
core   +1 more source

6-gingerol enhances ciprofloxacin efficacy by inhibiting NorA efflux pump in Staphylococcus aureus

The Microbe
The drug efflux mechanism adopted by Staphylococcus aureus helps it in its survival under antibiotic pressure. The efflux pump NorA, a member of the MFS superfamily, effluxes out fluoroquinolones, biocides, quaternary ammonium compounds, and anti ...
Shashikanta Sau, Sarika Sharma, Gopal L. Khatik, Sandeep Sharma, Nitin Pal Kalia   +4 more
doaj   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Genome-wide survey of efflux pump-coding genes associated with Cronobacter survival, osmotic adaptation, and persistence

, 2019
Microorganisms express various transmembrane complexes collectively known as efflux pumps that influence their survival under stressful growth conditions. Although efflux pumps are important in resistance to antibiotics, disinfectants, and preservatives,
Gopinath, Gopal R, Negrete, Flavia, Stephan, Roger; https://orcid.org/, Woo, JungHa, Tall, Ben D; https://orcid.org/, Eshwar, Athmanya, Fanning, Séamus; https://orcid.org/, Chase, Hannah R, Lee, YouYoung, Jang, Hyein, Nguyen, Scott; https://orcid.org/, Gangiredla, Jayanthi, Srikumar, Shabarinath; https://orcid.org/, Finkelstein, Samantha, Lehner, Angelika; https://orcid.org/, Patel, Isha R, Wang, Caroline Z   +16 more
core   +1 more source

Effect of Gold-conjugated Nanoparticle siRNA on Efflux Pump MexB Gene Expression in Clinical Isolates of Pseudomonas aeruginosa

Medical Journal of Babylon
Background: Pseudomonas aeruginosa is a prevalent nosocomial infection associated with significant mortality rates. Microorganisms, such as P. aeruginosa, possess the capacity to acquire a significant level of resistance to many drugs.
Farah M. Al-Qurashi, Wathiq Abbas Al-Draghi   +1 more
doaj   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Specificity and tunability of efflux pumps: A new role for the proton gradient?

PLoS Computational Biology
Efflux pumps that transport antibacterial drugs out of bacterial cells have broad specificity, commonly leading to broad spectrum resistance and limiting treatment strategies for infections.
Matthew Gerry, Duncan Kirby, Boian S Alexandrov, Dvira Segal, Anton Zilman   +4 more
doaj   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source