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Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
PharmaceuticsBacterial resistance is a growing problem worldwide, and the number of deaths due to drug resistance is increasing every year. We must pay great attention to bacterial resistance.
Lan Zhang +6 more
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Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Postępy Mikrobiologii - Advancements of Microbiology, 2022 Abstract Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs).
Sreekantan Abhirami P. +3 more
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Microbial Primer: Multidrug efflux pumps.
Microbiology (Reading, England), 2023 Multidrug efflux pumps are molecular machines that sit in the bacterial cell membrane and pump molecules out from either the periplasm or cytoplasm to outside the cell. While involved in a variety of biological roles, they are primarily known for their contribution to antibiotic resistance by limiting the intracellular accumulation of antimicrobial ...
Siasat, Pauline Ann +1 more
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Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis. [PDF]
PLoS ONE, 2013 BACKGROUND: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure ...
Fabrice Vincent Biot +9 more
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Microbiology Spectrum, 2023 NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal +6 more
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Frontiers in Microbiology, 2018 The Burkholderia cenocepacia epidemic ET12 lineage belongs to the genomovar IIIA including the reference strain J2315, a highly transmissible epidemic B. cenocepacia lineage.
Josselin Bodilis +6 more
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A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. [PDF]
PLoS Pathogens, 2018 Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside the cell. Efflux pump activity is typically increased in multi-drug resistant (MDR) pathogens; chemicals that inhibit efflux pumps may have potential for antibiotic ...
Abigail L Reens +8 more
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Efflux Pump Inhibitors against Nontuberculous Mycobacteria [PDF]
International Journal of Molecular Sciences, 2020 Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus encouraging an urgent need for the development of new drugs for the treatment of mycobacterial infections ...
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Introduction: Transporters, Porins, and Efflux Pumps [PDF]
Chemical Reviews, 2021 All living cells are surrounded by lipidic membranes that separate metabolic and macromolecular biosynthetic processes from external environments. Biological membranes vary dramatically in their composition and structures and are optimized by mega-annum of evolution to effectively carry out diverse biological functions including energy production ...
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Brazilian Journal of Infectious Diseases, 2013 Objectives: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree ...
Abeer Ahmed Rushdy +5 more
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