Results 201 to 210 of about 64,527 (310)

Point Mutation Analysis of the Drug Efflux Pump MexB in Clinical Isolates of <i>Pseudomonas aeruginosa</i>

Seiji Yamasaki, Naoki Koga, Ryosuke Nakashima, Mitsuko Hayashi-Nishino, Kunihiko Nishino   +4 more
openalex   +2 more sources

Insights from meta‐analysis for efficient docosahexaenoic acid production in thraustochytrids through advanced cultivation and fermentation strategies

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract This systematic review examines strategies for docosahexaenoic acid (DHA) production by thraustochytrids, focusing on cultivation techniques, fermentation technologies, and carbon/nitrogen optimization to increase productivity. Among 169 eligible articles, the 100 most productive studies (0.7–10.3 g DHA L−1 per day) were analyzed. Quantitative
Jhiovana Cristielly Carrera Silva da Costa, Lucas Araújo Guimarães, Andre da Luz de Freitas, Luciana Porto de Souza Vandenberghe, Gilberto Vinícius de Melo Pereira, Carlos Ricardo Soccol, Hervé Louis Ghislain Rogez   +6 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides. [PDF]

Elife
Lee KK, Łapińska U, Tolle G, Micaletto M, Zhang B, Phetsang W, Verderosa AD, Invergo BM, Westley J, Bebes A, Yuecel R, O'Neill PA, Farbos A, Jeffries AR, van Houte S, Caboni P, Blaskovich MAT, Housden BE, Tsaneva-Atanasova K, Pagliara S.   +19 more
europepmc   +1 more source

Author response: An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

, 2017
Zhao Wang, Guizhen Fan, Corey F. Hryc, James N. Blaza, Irina I. Serysheva, Michael F. Schmid, Wah Chiu, Ben F. Luisi, Dijun Du   +8 more
openalex   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Structural and functional analysis of the <i>Mycobacterium tuberculosis</i> MmpS5L5 efflux pump presages increased bedaquiline resistance. [PDF]

Proc Natl Acad Sci U S A
Fountain AJ, Böhning J, McLaughlin SH, Morgan TE, Edelstein PH, Troll M, Lamers MH, Bharat TAM, Luisi BF, Ramakrishnan L.   +9 more
europepmc   +1 more source

An Efficient System for Functional Hyper-expression of Multidrug Efflux Pumps in Saccharomyces cerevisiae

, 2004
Masakazu Niimi
openalex   +2 more sources

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The competition in the biopharmaceutical market is increasing due to the market entry of biosimilars and rising costs in research and development of new drugs. Hence, continuous manufacturing gained significant attention due to its potential in reducing production cycle times and costs, as well as the possibility of real‐time release testing ...
Mariana Carvalho, Ana Cruz, Cees Haringa, Marcel Ottens, Marieke Klijn   +4 more
wiley   +1 more source