Results 21 to 30 of about 64,527 (310)
Journal of Infection in Developing Countries, 2023 Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed.
Mehdi Mirzaii +7 more
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Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]
International Journal of Molecular Sciences, 2012 Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
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Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
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Efflux pumps and microbial biofilm formation
Infection, Genetics and Evolution, 2023 Biofilm-related infections are resistant forms of pathogens that are regarded as a medical problem, particularly due to the spread of multiple drug resistance. One of the factors associated with biofilm drug resistance is the presence of various types of efflux pumps in bacteria.
Mahdyeh Neghabi, Hajiagha +1 more
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A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.
PLoS ONE, 2015 Bacterial efflux pumps are active transport proteins responsible for resistance to selected biocides and antibiotics. It has been shown that production of efflux pumps is up-regulated in a number of highly pathogenic bacteria, including methicillin ...
Adam R Brown +9 more
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Terpenes as bacterial efflux pump inhibitors: A systematic review
Frontiers in Pharmacology, 2022 Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While molecular analyses have identified efflux pump expression as an essential mechanism underlying multidrug resistance, the targeted drug development has occurred ...
Kaio Jefté Santos De Oliveira Dias +10 more
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Efflux pump proteins in antifungal resistance [PDF]
Frontiers in Pharmacology, 2014 It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major facilitator superfamily (MFS) proteins contribute to the development of tolerance to antifungals in yeasts. For example, the azole resistant clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of Cdr1p and/or ...
Prasad, Rajendra, Rawal, Manpreet K.
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Antibiotics, 2023 One promising approach in treating antibiotic-resistant bacteria is to “break” resistances connected with antibacterial efflux by co-administering efflux pump inhibitors (EPIs) with antibiotics. Here, ten compounds, previously optimized to restore the susceptibility to ciprofloxacin (CIP) of norA-overexpressing Staphylococcus aureus, were evaluated for
Rampacci, Elisa +5 more
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Insight into the AcrAB-TolC Complex Assembly Process Learned from Competition Studies
Antibiotics, 2021 The RND family efflux pump AcrAB-TolC in E. coli and its homologs in other Gram-negative bacteria are major players in conferring multidrug resistance to the cells.
Prasangi Rajapaksha +5 more
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International Journal of Microbiology, 2021 Acinetobacter baumannii (A. baumannii) has developed several resistance mechanisms. The bacteria have been reported as origin of multiple outbreaks. This study aims to investigate the use of efflux pumps and quinolone resistance-associated genotypic ...
Noel-David Nogbou +9 more
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