Results 91 to 100 of about 59,758 (308)

Detection of AdeAB, TetA, and TetB efflux pump genes in clinical isolates of tetracycline-resistant Acinetobacter baumannii from patients of Suez Canal University Hospitals

BMC Microbiology
Background Acinetobacter baumannii is an opportunistic bacteria associated primarily with hospital-acquired infections. Its tendency to acquire or donate resistance genes to neighboring bacteria is a major concern.
Hasnaa Azab, Aya Mohamed Askar, Noha M. Abd El-Fadeal, Amira A. A. Othman, Amal H. Rayan, Sally Khattab   +5 more
doaj   +1 more source

Nb2C‐Reinforced Hydrogel Microneedle as Dual ROS‐Scavenging Platform to Promote Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
An advanced microneedle patch integrating niobium carbide nanosheets and curcumin is engineered for diabetic wound healing. The system enables dual ROS scavenging and NIR‐enhanced antimicrobial activity, effectively rebalancing the oxidative microenvironment, promoting macrophage repolarization and angiogenesis, and accelerating full‐thickness wound ...
Zhi Zheng, Heyan Huang, Xiangru Chen, Jie Fu, Zhiwei Sun, Mengjuan Tao, Jianwei Mao, Fei Zhang, Zhou Wan, Yuan Li, Dingan Wu, Chuchao Zhou, Yanqing Yang   +12 more
wiley   +1 more source

Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumannii

New Microbes and New Infections, 2019
Acinetobacter baumannii is an important human pathogen responsible for a various type of infections. These bacterial strains are generally resistant to numerous antibiotics.
S.H. Ardehali, T. Azimi, Fatemeh Fallah, M. Owrang, N. Aghamohammadi, L. Azimi   +5 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Naturally derived efflux pump inhibitor among tetracycline-resistant Acinetobacter baumannii isolates

Medical Journal of Babylon
Background: The antimicrobial resistance of Acinetobacter baumannii is of major concern. It is one of the commonly distributed nosocomial pathogens, and its strains are frequently reported to demonstrate resistance to the most routinely prescribed ...
Ruqaya Kareem Abass Al-ammery, Zainab Adil Ghani Chabuck   +1 more
doaj   +1 more source

Changes in the expression of mexB, mexY, and oprD in clinical Pseudomonas aeruginosa isolates

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Changes in expression levels of drug efflux pump genes, mexB and mexY, and porin gene oprD in Pseudomonas aeruginosa were investigated in this study. Fifty-five multidrug-resistant P. aeruginosa (MDRP) strains were compared with 26 drug-sensitive strains
Yoshimi MATSUMOTO, Seiji YAMASAKI, Kouhei HAYAMA, Ryota IINO, Hiroyuki NOJI, Akihito YAMAGUCHI, Kunihiko NISHINO   +6 more
doaj   +1 more source

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump [PDF]

, 2004
Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may
Boersma, A.W.M. (Anton), Brok, M. (Mariël), Burger, H. (Herman), Nooter, K. (Kees), Stoter, G. (Gerrit), Tol, H. van, Wiemer, E.A.C. (Erik)   +6 more
core   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting RE-CmeB in Campylobacter spp.

One Health Advances
RE-CmeABC is a variant of the efflux pump CmeABC in the major zoonotic pathogen Campylobacter, which is much more potent in conferring resistance to various antibiotics for the treatment of Campylobacter infections in both veterinary and medical clinics.
Shihong Li, Cheng Zhang, Wenjun Li, Shuigen Wan, Jin Kang, Yong Liu, Hexiang Huang, Hao Li, Longhua Yang, Yanhong Shang, Chenglong Li, Xiangdang Du, Hong Yao   +12 more
doaj   +1 more source

Efflux pumps as potential targets for biofilm inhibition

Frontiers in Microbiology
Biofilms account for a great deal of infectious diseases and contribute significantly to antimicrobial resistance. Efflux pumps confer antimicrobial resistance to microorganisms and involve multiple processes of biofilm formation. Efflux pump inhibitors (
Jingyi Ren, Meijuan Wang, Wenjuan Zhou, Zhonghao Liu   +3 more
doaj   +1 more source