Results 101 to 110 of about 59,758 (308)
A High Throughput Microfluidic Approach for the Continuous Manufacture of Ibuprofen Nanocrystals
Advanced Materials Technologies, EarlyView.A robust, continuous manufacturing platform using a high‐throughput microfluidic reactor addresses key scalability challenges in pharmaceutical production. This process efficiently generates crystalline ibuprofen nanoparticles with superior control over size and distribution.
Shorooq Abukhamees +5 more
wiley +1 more source
Frontiers in Microbiology, 2019 Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole (RP2), an efflux pump inhibitor (EPI) isolated from the soil ...
Rushikesh Tambat +11 more
doaj +1 more source
Transforming Growth Factor Alpha Stimulation of Mucosal Tissue Cultures from Head and Neck Squamous Cell Carcinoma Patients Increases Chemoresistance to Cisplatin [PDF]
, 2010 The monoclonal epidermal growth factor receptor ( EGFR) antibody cetuximab (Erbitux(TM)) was recently approved by the European Medicines Agency for the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) in combination ...
Baumeister, Philipp +3 more
core +1 more source
BLOC: Buildable and Linkable Organ on a Chip
Advanced Materials Technologies, EarlyView.We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura +7 more
wiley +1 more source
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. [PDF]
, 2008 Objective: Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKCa agonist.
Beuers, U. +5 more
core +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Iranian South Medical Journal, 2014 Backgrand: Multi-drug resistance due to Acinetobacter baumannii strains has become a significant challenge. Efflux pump plays a vital role in the development of resistance in this bacteria.
Ali Reza JaponiNejad +2 more
doaj
Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.
Anticancer research, 2012 Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well ...
Amaral, Leonard +6 more
openaire +2 more sources
Advanced Science, EarlyView.This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen +11 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyObjectiveEmerging drug resistance in Pseudomonas aeruginosa is of great concern in clinical settings. P. aeruginosa activates its efflux-pump system in order to evade the effect of antibiotics.
Muhammad Bilal Habib +6 more
doaj +1 more source